Recent Advances in Antiviral Interferon-stimulated Gene Biology

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2018 Mar 24

PMID 29568506

Citations 40

Authors

John W Schoggins

Affiliations

Soon will be listed here.

Abstract

The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective roles . This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response.

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