Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus

Overview

Journal Int J Inflam

Publisher Wiley

Date 2018 Mar 24

PMID 29568481

Citations 17

Authors

Lusine Khondkaryan

Sona Margaryan

David Poghosyan

Gayane Manukyan

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNF ( < 0.01) and expression of CD11b ( < 0.001) and TLR4 ( < 0.001) compared to those in monocytes from healthy subjects. Furthermore, LPS-induced IL-10 levels were similar in diabetic and healthy supernatants, while expression levels of CD163 were found to be downregulated on monocytes from T2DM ( < 0.001) suggesting impaired ability of monocytes to switch their phenotype to anti-inflammatory. Taken together, our results suggest compromised function of monocytes in T2DM, which may explain, at least partly, high incidence of infection in these patients.

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