Intra-operative Characterisation of Subthalamic Oscillations in Parkinson's Disease

Overview

Journal Clin Neurophysiol

Publisher Elsevier

Specialties Neurology
Psychiatry

Date 2018 Mar 24

PMID 29567582

Citations 7

Authors

Xinyi Geng

Xin Xu

Andreas Horn

Ningfei Li

Zhipei Ling

Peter Brown

Shouyan Wang

Affiliations

Soon will be listed here.

Abstract

Objective: This study aims to use the activities recorded directly from the deep brain stimulation (DBS) electrode to address the focality and distinct nature of the local field potential (LFP) activities of different frequency.

Methods: Pre-operative and intra-operative magnetic resonance imaging (MRI) were acquired from patients with Parkinson's disease (PD) who underwent DBS in the subthalamic nucleus and intra-operative LFP recording at rest and during cued movements. Images were reconstructed and 3-D visualized using Lead-DBS® toolbox to determine the coordinates of contact. The resting spectral power and movement-related power modulation of LFP oscillations were estimated.

Results: Both subthalamic LFP activity recorded at rest and its modulation by movement had focal maxima in the alpha, beta and gamma bands. The spatial distribution of alpha band activity and its modulation was significantly different to that in the beta band. Moreover, there were significant differences in the scale and timing of movement related modulation across the frequency bands.

Conclusion: Subthalamic LFP activities within specific frequency bands can be distinguished by spatial topography and pattern of movement related modulation.

Significance: Assessment of the frequency, focality and pattern of movement related modulation of subthalamic LFPs reveals a heterogeneity of neural population activity in this region. This could potentially be leveraged to finesse intra-operative targeting and post-operative contact selection.

Citing Articles

N2GNet tracks gait performance from subthalamic neural signals in Parkinson's disease.

Choi J, Cui C, Wilkins K, Bronte-Stewart H NPJ Digit Med. 2025; 8(1):7.

PMID: 39755754 PMC: 11700158. DOI: 10.1038/s41746-024-01364-6.

N2GNet tracks gait performance from subthalamic neural signals in Parkinson's disease.

Choi J, Cui C, Wilkins K, Bronte-Stewart H Res Sq. 2024; .

PMID: 39574884 PMC: 11581115. DOI: 10.21203/rs.3.rs-5112726/v1.

Spectral Topography of the Subthalamic Nucleus to Inform Next-Generation Deep Brain Stimulation.

Averna A, Debove I, Nowacki A, Peterman K, Duchet B, Sousa M Mov Disord. 2023; 38(5):818-830.

PMID: 36987385 PMC: 7615852. DOI: 10.1002/mds.29381.

Early decreases in cortical mid-gamma peaks coincide with the onset of motor deficits and precede exaggerated beta build-up in rat models for Parkinson's disease.

Brazhnik E, Novikov N, McCoy A, Ilieva N, Ghraib M, Walters J Neurobiol Dis. 2021; 155:105393.

PMID: 34000417 PMC: 8422282. DOI: 10.1016/j.nbd.2021.105393.

Directional Local Field Potentials in the Subthalamic Nucleus During Deep Brain Implantation of Parkinson's Disease Patients.

Nguyen T, Schupbach M, Mercanzini A, Dransart A, Pollo C Front Hum Neurosci. 2020; 14:521282.

PMID: 33192384 PMC: 7556345. DOI: 10.3389/fnhum.2020.521282.

References

Horn A, Kuhn A . Lead-DBS: a toolbox for deep brain stimulation electrode localizations and visualizations. Neuroimage. 2014; 107:127-135. DOI: 10.1016/j.neuroimage.2014.12.002. View

Ray N, Jenkinson N, Wang S, Holland P, Brittain J, Joint C . Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Exp Neurol. 2008; 213(1):108-13. DOI: 10.1016/j.expneurol.2008.05.008. View

Steiner L, Neumann W, Staub-Bartelt F, Herz D, Tan H, Pogosyan A . Subthalamic beta dynamics mirror Parkinsonian bradykinesia months after neurostimulator implantation. Mov Disord. 2017; 32(8):1183-1190. PMC: 5575541. DOI: 10.1002/mds.27068. View

Kuhn A, Kempf F, Brucke C, Gaynor Doyle L, Martinez-Torres I, Pogosyan A . High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance. J Neurosci. 2008; 28(24):6165-73. PMC: 6670522. DOI: 10.1523/JNEUROSCI.0282-08.2008. View

Yoshida F, Martinez-Torres I, Pogosyan A, Holl E, Petersen E, Chen C . Value of subthalamic nucleus local field potentials recordings in predicting stimulation parameters for deep brain stimulation in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2010; 81(8):885-9. DOI: 10.1136/jnnp.2009.190918. View

Bour L, Lourens M, Verhagen R, de Bie R, van den Munckhof P, Schuurman P . Directional Recording of Subthalamic Spectral Power Densities in Parkinson's Disease and the Effect of Steering Deep Brain Stimulation. Brain Stimul. 2015; 8(4):730-41. DOI: 10.1016/j.brs.2015.02.002. View

Shimamoto S, Ryapolova-Webb E, Ostrem J, Galifianakis N, Miller K, Starr P . Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease. J Neurosci. 2013; 33(17):7220-33. PMC: 3673303. DOI: 10.1523/JNEUROSCI.4676-12.2013. View

Jenkinson N, Kuhn A, Brown P . γ oscillations in the human basal ganglia. Exp Neurol. 2012; 245:72-6. DOI: 10.1016/j.expneurol.2012.07.005. View

Fogelson N, Pogosyan A, Kuhn A, Kupsch A, van Bruggen G, Speelman H . Reciprocal interactions between oscillatory activities of different frequencies in the subthalamic region of patients with Parkinson's disease. Eur J Neurosci. 2005; 22(1):257-66. DOI: 10.1111/j.1460-9568.2005.04179.x. View

10.

Reck C, Florin E, Wojtecki L, Groiss S, Voges J, Sturm V . Differential distribution of coherence between beta-band subthalamic oscillations and forearm muscles in Parkinson's disease during isometric contraction. Clin Neurophysiol. 2009; 120(8):1601-9. DOI: 10.1016/j.clinph.2009.05.018. View

11.

Jakab A, Blanc R, Berenyi E, Szekely G . Generation of individualized thalamus target maps by using statistical shape models and thalamocortical tractography. AJNR Am J Neuroradiol. 2012; 33(11):2110-6. PMC: 7965575. DOI: 10.3174/ajnr.A3140. View

12.

Brittain J, Brown P . Oscillations and the basal ganglia: motor control and beyond. Neuroimage. 2013; 85 Pt 2:637-47. PMC: 4813758. DOI: 10.1016/j.neuroimage.2013.05.084. View

13.

Alegre M, Valencia M . Oscillatory activity in the human basal ganglia: more than just beta, more than just Parkinson's disease. Exp Neurol. 2013; 248:183-6. DOI: 10.1016/j.expneurol.2013.05.018. View

14.

Miyagi Y, Okamoto T, Morioka T, Tobimatsu S, Nakanishi Y, Aihara K . Spectral analysis of field potential recordings by deep brain stimulation electrode for localization of subthalamic nucleus in patients with Parkinson's disease. Stereotact Funct Neurosurg. 2009; 87(4):211-8. DOI: 10.1159/000225974. View

15.

Levy R, Ashby P, Hutchison W, Lang A, Lozano A, Dostrovsky J . Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease. Brain. 2002; 125(Pt 6):1196-209. DOI: 10.1093/brain/awf128. View

16.

Pollo C, Kaelin-Lang A, Oertel M, Stieglitz L, Taub E, Fuhr P . Directional deep brain stimulation: an intraoperative double-blind pilot study. Brain. 2014; 137(Pt 7):2015-26. DOI: 10.1093/brain/awu102. View

17.

Horn A, Neumann W, Degen K, Schneider G, Kuhn A . Toward an electrophysiological "sweet spot" for deep brain stimulation in the subthalamic nucleus. Hum Brain Mapp. 2017; 38(7):3377-3390. PMC: 6867148. DOI: 10.1002/hbm.23594. View

18.

Tan H, Pogosyan A, Anzak A, Foltynie T, Limousin P, Zrinzo L . Frequency specific activity in subthalamic nucleus correlates with hand bradykinesia in Parkinson's disease. Exp Neurol. 2012; 240:122-9. PMC: 3605592. DOI: 10.1016/j.expneurol.2012.11.011. View

19.

Marmor O, Valsky D, Joshua M, Bick A, Arkadir D, Tamir I . Local vs. volume conductance activity of field potentials in the human subthalamic nucleus. J Neurophysiol. 2017; 117(6):2140-2151. PMC: 5454468. DOI: 10.1152/jn.00756.2016. View

20.

Kolb R, Abosch A, Felsen G, Thompson J . Use of intraoperative local field potential spectral analysis to differentiate basal ganglia structures in Parkinson's disease patients. Physiol Rep. 2017; 5(12. PMC: 5492209. DOI: 10.14814/phy2.13322. View