Mesenchymal Stem Cell Therapy for Paraquat Poisoning: A Systematic Review and Meta-analysis of Preclinical Studies

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Mar 23

PMID 29566055

Citations 17

Authors

Fang He

Aiting Zhou

Shou Feng

Yuxiang Li

Tao Liu

Affiliations

Soon will be listed here.

Abstract

Background: Paraquat (PQ) poisoning can cause multiple organ failure, in which the lung is the primary target organ. There is currently no treatment for PQ poisoning. Mesenchymal stem cells (MSCs), which differentiate into multiple cell types, have generated much enthusiasm regarding their use for the treatment of several diseases. The aim of this study was to systematically review and analyze published preclinical studies describing MSC administration for the treatment of PQ poisoning in animal models to provide a basis for cell therapy.

Methods: The electronic databases PubMed and CBMdisc were searched in this systematic review and meta-analysis. The MSC treatment characteristics of animal models of PQ poisoning were summarized. After quality assessment was performed, the effects of MSC transplantation were evaluated based on the survival rate, lung wet/dry weight, fibrosis scores, oxidative stress response, and inflammatory response. Publication bias was assessed.

Results: Eleven controlled preclinical studies involving MSC transplantation in animal models of PQ poisoning were included in this review. MSC therapy improved the survival rate and reduced the lung wet/dry weight and histopathological fibrosis changes in most studies. MSCs decreased serum or plasma malondialdehyde levels in the acute phase after 7 and 14 d and increased serum or plasma superoxide dismutase and glutathione levels at the same time points. IL-1β, TNF-α and TGF-β1 levels in blood or lung tissues were decreased to different degrees by MSCs. Lung hydroxyproline was decreased by MSCs after 14 d. No obvious evidence of publication bias was found.

Conclusion: MSCs showed anti-fibrosis therapeutic effects in animal models of lung injury caused by PQ poisoning, which may be related to reduced oxidative stress and inflammatory cytokine levels. Our review indicates a potential therapeutic role for MSC therapy to treat PQ poisoning and serves to augment the rationale for clinical studies.

Citing Articles

Mesenchymal stem cell-based therapy for paraquat-induced lung injury.

Zhang X, Li T, Lu Y Cell Biol Toxicol. 2024; 40(1):70.

PMID: 39136896 PMC: 11322247. DOI: 10.1007/s10565-024-09911-3.

Mechanism of action of miR-15a-5p and miR-152-3p in paraquat-induced pulmonary fibrosis through Wnt/β-catenin signaling mediation.

Liu D, Guan Y PeerJ. 2024; 12:e17662.

PMID: 38993979 PMC: 11238725. DOI: 10.7717/peerj.17662.

Paracrine- and cell-contact-mediated immunomodulatory effects of human periodontal ligament-derived mesenchymal stromal cells on CD4 T lymphocytes.

Behm C, Milek O, Rausch-Fan X, Moritz A, Andrukhov O Stem Cell Res Ther. 2024; 15(1):154.

PMID: 38816862 PMC: 11141051. DOI: 10.1186/s13287-024-03759-4.

Autologous Stem Cells Transplants in the Treatment of Temporomandibular Joints Disorders: A Systematic Review and Meta-Analysis of Clinical Trials.

Checinski M, Checinska K, Turosz N, Kaminska M, Nowak Z, Sikora M Cells. 2022; 11(17).

PMID: 36078117 PMC: 9454527. DOI: 10.3390/cells11172709.

Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review.

Ahmadi A, Mortazavi Z, Mehri S, Hosseinzadeh H Naunyn Schmiedebergs Arch Pharmacol. 2022; 395(11):1297-1329.

PMID: 35676380 DOI: 10.1007/s00210-022-02258-8.

References

Chen X, Wang S, Cao W . Mesenchymal stem cell-mediated immunomodulation in cell therapy of neurodegenerative diseases. Cell Immunol. 2017; 326:8-14. DOI: 10.1016/j.cellimm.2017.06.006. View

Guo F, Sun Y, Su L, Li S, Liu Z, Hu X . Losartan attenuates paraquat-induced pulmonary fibrosis in rats. Hum Exp Toxicol. 2014; 34(5):497-505. DOI: 10.1177/0960327114543840. View

Wang X, Luo F, Zhao H . Paraquat-induced reactive oxygen species inhibit neutrophil apoptosis via a p38 MAPK/NF-κB-IL-6/TNF-α positive-feedback circuit. PLoS One. 2014; 9(4):e93837. PMC: 3979731. DOI: 10.1371/journal.pone.0093837. View

Neves F, Sousa R, Pazin-Filho A, Cupo P, Elias Junior J, Nogueira-Barbosa M . Severe paraquat poisoning: clinical and radiological findings in a survivor. J Bras Pneumol. 2010; 36(4):513-6. DOI: 10.1590/s1806-37132010000400019. View

Wang W, Pei X, Xu M, Sun S, Zhang C, Mu K . The Protective Effect of Sodium Ferulate and Oxymatrine Combination on Paraquat-induced Lung Injury. Iran J Pharm Res. 2015; 14(2):573-83. PMC: 4403075. View

Papaccio F, Paino F, Regad T, Papaccio G, Desiderio V, Tirino V . Concise Review: Cancer Cells, Cancer Stem Cells, and Mesenchymal Stem Cells: Influence in Cancer Development. Stem Cells Transl Med. 2017; 6(12):2115-2125. PMC: 5702541. DOI: 10.1002/sctm.17-0138. View

Hooijmans C, Rovers M, De Vries R, Leenaars M, Ritskes-Hoitinga M, Langendam M . SYRCLE's risk of bias tool for animal studies. BMC Med Res Methodol. 2014; 14:43. PMC: 4230647. DOI: 10.1186/1471-2288-14-43. View

Yao R, Zhou Y, He Y, Jiang Y, Liu P, Ye L . Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress. Exp Ther Med. 2014; 9(1):131-136. PMC: 4247297. DOI: 10.3892/etm.2014.2073. View

Roux J, Kawakatsu H, Gartland B, Pespeni M, Sheppard D, Matthay M . Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem. 2005; 280(19):18579-89. DOI: 10.1074/jbc.M410561200. View

10.

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009; 62(10):1006-12. DOI: 10.1016/j.jclinepi.2009.06.005. View

11.

Patel B, Wilson M, ODea K, Takata M . TNF-induced death signaling triggers alveolar epithelial dysfunction in acute lung injury. J Immunol. 2013; 190(8):4274-82. PMC: 3701855. DOI: 10.4049/jimmunol.1202437. View

12.

Mukherjee S, Kolb M, Duan F, Janssen L . Transforming growth factor-β evokes Ca2+ waves and enhances gene expression in human pulmonary fibroblasts. Am J Respir Cell Mol Biol. 2012; 46(6):757-64. DOI: 10.1165/rcmb.2011-0223OC. View

13.

Lee I, Lin C, Wu Y, Yang C . TNF-alpha induces matrix metalloproteinase-9 expression in A549 cells: role of TNFR1/TRAF2/PKCalpha-dependent signaling pathways. J Cell Physiol. 2010; 224(2):454-64. DOI: 10.1002/jcp.22142. View

14.

Moodley Y, Atienza D, Manuelpillai U, Samuel C, Tchongue J, Ilancheran S . Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol. 2009; 175(1):303-13. PMC: 2708816. DOI: 10.2353/ajpath.2009.080629. View

15.

Yang C, Song H, Liu W, Dong X, Liu Z . Protective Effects of Chymostatin on Paraquat-Induced Acute Lung Injury in Mice. Inflammation. 2017; 41(1):122-133. DOI: 10.1007/s10753-017-0670-x. View

16.

Gawarammana I, Buckley N . Medical management of paraquat ingestion. Br J Clin Pharmacol. 2011; 72(5):745-57. PMC: 3243009. DOI: 10.1111/j.1365-2125.2011.04026.x. View

17.

Giacomelli E, Mummery C, Bellin M . Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes. Cell Mol Life Sci. 2017; 74(20):3711-3739. PMC: 5597692. DOI: 10.1007/s00018-017-2546-5. View

18.

Conese M, Piro D, Carbone A, Castellani S, Di Gioia S . Hematopoietic and mesenchymal stem cells for the treatment of chronic respiratory diseases: role of plasticity and heterogeneity. ScientificWorldJournal. 2014; 2014:859817. PMC: 3916026. DOI: 10.1155/2014/859817. View

19.

Liu H, Ding Y, Hou Y, Zhao G, Lu Y, Chen X . [The protective effect of bone marrow mesenchymal stem cells carrying antioxidant gene superoxide dismutase on paraquat lung injury in mice]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016; 34(1):1-7. DOI: 10.3760/cma.j.issn.1001-9391.2016.01.001. View

20.

Yang H, Wen Y, Hou-you Y, Yu-tong W, Chuan-ming L, Jian X . Combined treatment with bone marrow mesenchymal stem cells and methylprednisolone in paraquat-induced acute lung injury. BMC Emerg Med. 2013; 13 Suppl 1:S5. PMC: 3701473. DOI: 10.1186/1471-227X-13-S1-S5. View