The Clinicopathological and Prognostic Value of HSP27 in Hepatocellular Carcinoma: a Systematic Review and Meta-analysis

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2018 Mar 23

PMID 29563808

Citations 6

Authors

Chaojie Liang

Yingchen Xu

Hua Ge

Guangming Li

Jixiang Wu

Affiliations

Soon will be listed here.

Abstract

Background: In the recent past, there is increasing evidence demonstrating that HSP27 plays a key role in tumor progression. However, the relationship between HSP27 expression and the clinicopathological features of hepatocellular carcinoma (HCC), as well as its prognostic value in HCC patients remain controversial. Accordingly, we conducted a meta-analysis to assess the correlation between HSP27 expression and HCC, and determine the prognostic value of HSP27 in HCC.

Methods: The data included clinicopathological features and survival information extracted from the published literature in the databases PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, and Wan Fang. The pooled odds ratios and hazard ratios with 95% CIs were calculated using Forest plot analysis.

Results: The meta-analysis results indicated that the positive HSP27 expression was significantly correlated with HCC incidence, tumor differentiation, and α-fetoprotein level in patients with HCC. However, the expression of HSP27 was not associated with metastasis, hepatitis B virus surface antigen, gender, tumor size, TNM stage, and vascular invasion. Additionally, HSP27 expression indicated a poor overall survival rate, but it was not related to disease-free survival rate.

Conclusion: This meta-analysis revealed that HSP27 may play a key role in the development of HCC and could be a reliable biomarker for the prognosis of patients with HCC. However, additional high-quality research is needed to support the results.

Citing Articles

Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B.

Yousefli Z, Meshkat Z, Ghayour-Mobarhan M, Hosseini S, Tavallaie S, Kazemianfar E Indian J Clin Biochem. 2024; 39(3):365-372.

PMID: 39005869 PMC: 11239617. DOI: 10.1007/s12291-023-01114-7.

Clinicopathological and prognostic significance of heat shock proteins in hepatocellular carcinoma: a systematic review and meta-analysis.

Xiang D, Jiang M, Chen Y, Liu C, Li L Front Oncol. 2023; 13:1169979.

PMID: 37601679 PMC: 10436519. DOI: 10.3389/fonc.2023.1169979.

Discovery of Novel HSP27 Inhibitors as Prospective Anti-Cancer Agents Utilizing Computer-Assisted Therapeutic Discovery Approaches.

Umar H, Ajayi A, Mukerjee N, Aborode A, Hasan M, Maitra S Cells. 2022; 11(15).

PMID: 35954254 PMC: 9368632. DOI: 10.3390/cells11152412.

The Role of Hsp27 in Chemotherapy Resistance.

Lampros M, Vlachos N, Voulgaris S, Alexiou G Biomedicines. 2022; 10(4).

PMID: 35453647 PMC: 9028095. DOI: 10.3390/biomedicines10040897.

Serum levels of anti-heat shock protein 27 antibodies in patients with chronic liver disease.

Gruden G, Carucci P, Barutta F, Burt D, Ferro A, Rolle E Cell Stress Chaperones. 2020; 26(1):151-157.

PMID: 32895883 PMC: 7736373. DOI: 10.1007/s12192-020-01164-3.

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