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Alzheimer's Disease and Sleep-Wake Disturbances: Amyloid, Astrocytes, and Animal Models

Overview
Journal J Neurosci
Specialty Neurology
Date 2018 Mar 23
PMID 29563238
Citations 32
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Abstract

Sleep-wake abnormalities are common in patients with Alzheimer's disease, and can be a major reason for institutionalization. However, an emerging concept is that these sleep-wake disturbances are part of the causal pathway accelerating the neurodegenerative process. Recently, new findings have provided intriguing evidence for a positive feedback loop between sleep-wake dysfunction and β-amyloid (Aβ) aggregation. Studies in both humans and animal models have shown that extended periods of wakefulness increase Aβ levels and aggregation, and accumulation of Aβ causes fragmentation of sleep. This perspective is aimed at presenting evidence supporting causal links between sleep-wake dysfunction and aggregation of Aβ peptide in Alzheimer's disease, and explores the role of astrocytes, a specialized type of glial cell, in this context underlying Alzheimer's disease pathology. The utility of current animal models and the unexplored potential of alternative animal models for testing mechanisms involved in the reciprocal relationship between sleep disruption and Aβ are also discussed..

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References
1.
Price J, Morris J . Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol. 1999; 45(3):358-68. DOI: 10.1002/1531-8249(199903)45:3<358::aid-ana12>3.0.co;2-x. View

2.
McCurry S, Logsdon R, Teri L, Gibbons L, Kukull W, Bowen J . Characteristics of sleep disturbance in community-dwelling Alzheimer's disease patients. J Geriatr Psychiatry Neurol. 1999; 12(2):53-9. DOI: 10.1177/089198879901200203. View

3.
Hendricks J, Finn S, Panckeri K, Chavkin J, Williams J, Sehgal A . Rest in Drosophila is a sleep-like state. Neuron. 2000; 25(1):129-38. DOI: 10.1016/s0896-6273(00)80877-6. View

4.
Shaw P, Cirelli C, Greenspan R, Tononi G . Correlates of sleep and waking in Drosophila melanogaster. Science. 2000; 287(5459):1834-7. DOI: 10.1126/science.287.5459.1834. View

5.
Fortini M, Skupski M, Boguski M, Hariharan I . A survey of human disease gene counterparts in the Drosophila genome. J Cell Biol. 2000; 150(2):F23-30. PMC: 2180233. DOI: 10.1083/jcb.150.2.f23. View