Using Polygenic Risk Scores to Establish Endophenotypes: Considerations and Current Constraints

Overview

Journal Biol Psychiatry Cogn Neurosci Neuroimaging

Specialties Neurology
Psychiatry
Radiology

Date 2018 Mar 22

PMID 29560914

Citations 3

Authors

David C Glahn

Andrew M McIntosh

Affiliations

Soon will be listed here.

Citing Articles

Migraine polygenic risk score associates with efficacy of migraine-specific drugs.

Kogelman L, Esserlind A, Francke Christensen A, Awasthi S, Ripke S, Ingason A Neurol Genet. 2019; 5(6):e364.

PMID: 31872049 PMC: 6878840. DOI: 10.1212/NXG.0000000000000364.

Violence exposure in an urban city: A GxE interaction with aggressive and impulsive behaviors.

Musci R, Bettencourt A, Sisto D, Maher B, Masyn K, Ialongo N J Child Psychol Psychiatry. 2018; 60(1):72-81.

PMID: 30159911 PMC: 6392042. DOI: 10.1111/jcpp.12966.

Cognitive genomics: Searching for the genetic roots of neuropsychological functioning.

Bearden C, Glahn D Neuropsychology. 2018; 31(8):1003-1019.

PMID: 29376674 PMC: 5791763. DOI: 10.1037/neu0000412.

References

Dudbridge F . Power and predictive accuracy of polygenic risk scores. PLoS Genet. 2013; 9(3):e1003348. PMC: 3605113. DOI: 10.1371/journal.pgen.1003348. View

. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014; 511(7510):421-7. PMC: 4112379. DOI: 10.1038/nature13595. View

Carey C, Knodt A, Conley E, Hariri A, Bogdan R . Reward-related ventral striatum activity links polygenic risk for attention-deficit/hyperactivity disorder to problematic alcohol use in young adulthood. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017; 2(2):180-187. PMC: 5560771. DOI: 10.1016/j.bpsc.2016.10.003. View

Purcell S, Wray N, Stone J, Visscher P, ODonovan M, Sullivan P . Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature. 2009; 460(7256):748-52. PMC: 3912837. DOI: 10.1038/nature08185. View

Iossifov I, ORoak B, Sanders S, Ronemus M, Krumm N, Levy D . The contribution of de novo coding mutations to autism spectrum disorder. Nature. 2014; 515(7526):216-21. PMC: 4313871. DOI: 10.1038/nature13908. View