The Associations Between Plasma Phytoestrogens Concentration and Metabolic Syndrome Risks in Chinese Population

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Mar 21

PMID 29558501

Citations 9

Authors

Jie Liu

Shengquan Mi

Li Du

Xiang Li

Peiqin Li

Keyu Jia

Jing Zhao

Hong Zhang

Wenhua Zhao

Ying Gao

Affiliations

Soon will be listed here.

Abstract

Metabolic syndrome (MetS) has become an important issue in the healthcare systems of both developed and developing countries. Phytoestrogens have shown estrogenic effects, which may involve in the etiology of MetS. The current study consisted of 293 MetS cases and 264 healthy controls. The concentrations of seven plasma phytoestrogens (daidzein, genistein, glycitein, equol, enterolactone, enterodiol and coumestrol) were detected by UPLC-MS/MS. Adjusted unconditional logistic regression was used to assess the associations between plasma phytoestrogens concentration and risks of MetS, as well as the associations between plasma phytoestrogens concentration and MetS components. Linear regression was used to evaluate the associations between equol concentration in equol-producers and MetS components. Higher concentrations of total isoflavone and equol were associated with decreased risk of MetS. The equol concentration was negatively associated with waist circumference and positively associated with HDL-C level. Increased daidzein was associated with both lower waist circumference and lower fasting blood glucose levels. Our results suggested that higher plasma total isoflavone, equol and daidzein might decrease MetS risk.

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References

Struja T, Richard A, Linseisen J, Eichholzer M, Rohrmann S . The association between urinary phytoestrogen excretion and components of the metabolic syndrome in NHANES. Eur J Nutr. 2014; 53(6):1371-81. DOI: 10.1007/s00394-013-0639-y. View

van der Schouw Y, Sampson L, Willett W, Rimm E . The usual intake of lignans but not that of isoflavones may be related to cardiovascular risk factors in U.S. men. J Nutr. 2005; 135(2):260-6. DOI: 10.1093/jn/135.2.260. View

Audet-Walsh E, Giguere V . The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases. Acta Pharmacol Sin. 2014; 36(1):51-61. PMC: 4571319. DOI: 10.1038/aps.2014.121. View

Akaza H, Miyanaga N, Takashima N, Naito S, Hirao Y, Tsukamoto T . Comparisons of percent equol producers between prostate cancer patients and controls: case-controlled studies of isoflavones in Japanese, Korean and American residents. Jpn J Clin Oncol. 2004; 34(2):86-9. DOI: 10.1093/jjco/hyh015. View

Breithofer A, Graumann K, Scicchitano M, Karathanasis S, Butt T, Jungbauer A . Regulation of human estrogen receptor by phytoestrogens in yeast and human cells. J Steroid Biochem Mol Biol. 1999; 67(5-6):421-9. DOI: 10.1016/s0960-0760(98)00139-3. View

Hong K, Ko K, Ahn Y, Kim C, Park S, Park J . Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype. Genes Nutr. 2012; 7(4):567-74. PMC: 3448036. DOI: 10.1007/s12263-012-0292-8. View

Jungbauer A, Medjakovic S . Phytoestrogens and the metabolic syndrome. J Steroid Biochem Mol Biol. 2013; 139:277-89. DOI: 10.1016/j.jsbmb.2012.12.009. View

Mueller M, Hobiger S, Jungbauer A . Red clover extract: a source for substances that activate peroxisome proliferator-activated receptor alpha and ameliorate the cytokine secretion profile of lipopolysaccharide-stimulated macrophages. Menopause. 2010; 17(2):379-87. DOI: 10.1097/gme.0b013e3181c94617. View

Vedavanam K, Srijayanta S, OReilly J, Raman A, Wiseman H . Antioxidant action and potential antidiabetic properties of an isoflavonoid-containing soyabean phytochemical extract (SPE). Phytother Res. 1999; 13(7):601-8. DOI: 10.1002/(sici)1099-1573(199911)13:7<601::aid-ptr550>3.0.co;2-o. View

10.

Washburn S, Burke G, Morgan T, Anthony M . Effect of soy protein supplementation on serum lipoproteins, blood pressure, and menopausal symptoms in perimenopausal women. Menopause. 1999; 6(1):7-13. View

11.

Li Z, Hong K, Saltsman P, DeShields S, Bellman M, Thames G . Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein. Eur J Clin Nutr. 2005; 59(3):411-8. DOI: 10.1038/sj.ejcn.1602089. View

12.

Saarinen N, Bingham C, Lorenzetti S, Mortensen A, Makela S, Penttinen P . Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network "Phytohealth" (QLKI-2002-2453). Genes Nutr. 2008; 1(3-4):143-58. PMC: 3454835. DOI: 10.1007/BF02829964. View

13.

Grundy S, Brewer Jr H, Cleeman J, Smith Jr S, Lenfant C . Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004; 109(3):433-8. DOI: 10.1161/01.CIR.0000111245.75752.C6. View

14.

Merritt J . Metabolic syndrome: soybean foods and serum lipids. J Natl Med Assoc. 2004; 96(8):1032-41. PMC: 2568482. View

15.

Baum J, Teng H, Erdman Jr J, Weigel R, Klein B, Persky V . Long-term intake of soy protein improves blood lipid profiles and increases mononuclear cell low-density-lipoprotein receptor messenger RNA in hypercholesterolemic, postmenopausal women. Am J Clin Nutr. 1998; 68(3):545-51. DOI: 10.1093/ajcn/68.3.545. View

16.

Sathyamoorthy N, Wang T . Differential effects of dietary phyto-oestrogens daidzein and equol on human breast cancer MCF-7 cells. Eur J Cancer. 1998; 33(14):2384-9. DOI: 10.1016/s0959-8049(97)00303-1. View

17.

Barros R, Gustafsson J . Estrogen receptors and the metabolic network. Cell Metab. 2011; 14(3):289-99. DOI: 10.1016/j.cmet.2011.08.005. View

18.

Jayagopal V, Albertazzi P, Kilpatrick E, Howarth E, Jennings P, Hepburn D . Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care. 2002; 25(10):1709-14. DOI: 10.2337/diacare.25.10.1709. View

19.

Grace P, Taylor J, Botting N, Fryatt T, Oldfield M, Al-Maharik N . Quantification of isoflavones and lignans in serum using isotope dilution liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2003; 17(12):1350-1357. DOI: 10.1002/rcm.1059. View

20.

Squadrito F, Marini H, Bitto A, Altavilla D, Polito F, Adamo E . Genistein in the metabolic syndrome: results of a randomized clinical trial. J Clin Endocrinol Metab. 2013; 98(8):3366-74. DOI: 10.1210/jc.2013-1180. View