Increasing Negative Lymph Node Count Predicts Favorable OS and DSS in Breast Cancer with Different Lymph Node-positive Subgroups

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Mar 20

PMID 29554092

Citations 2

Authors

Xin Zhao

Jing Wei

Xiaoxin Li

Haochang Yang

Pei Wang

Susheng Cao

Affiliations

Soon will be listed here.

Abstract

Adequate lymph node evaluation is recommended for optimal staging in patients with malignant neoplasms including breast cancer. However, the role of negative lymph nodes (LNs) remains unclear in breast cancer according to N substage (N1, N2, and N3). In this study, for the first time, we analyzed the prognostic significance of negative LNs in breast cancer patients. A critical relationship was observed between negative LN count and survival, independent of patient characteristics and other related molecular variables including estrogen receptor (PR) status, progesterone receptor (ER) status, human epidermal growth factor receptor 2 (HER2) status, depth of tumor invasion and degree of differentiation. This research is of great importance in providing more information about the prognosis of breast cancer by statistical analysis of negative lymph nodes and can serve as a useful supplement to the current pathological system.

Citing Articles

Role of Removed Lymph Nodes on the Prognosis of M0 Small-Bowel Neuroendocrine Tumors: a Propensity Score Matching Analysis from SEER Database.

Xie J, Pang Y, Li X, Wu X J Gastrointest Surg. 2021; 25(12):3188-3197.

PMID: 34109533 PMC: 8654718. DOI: 10.1007/s11605-021-04994-3.

The Number of Negative Lymph Nodes is Positively Associated with Survival in Esophageal Squamous Cell Carcinoma Patients in China.

Yu L, Zhang X, Guan S, Cheng Y, Li L Open Med (Wars). 2020; 15:152-159.

PMID: 32190739 PMC: 7065439. DOI: 10.1515/med-2020-0023.

References

Rosen P, Lesser M, Kinne D, BEATTIE E . Discontinuous or "skip" metastases in breast carcinoma. Analysis of 1228 axillary dissections. Ann Surg. 1983; 197(3):276-83. PMC: 1352730. DOI: 10.1097/00000658-198303000-00006. View

Aslam M, Venkatesh J, Jameson J, West K, Pringle J, Singh B . Identification of high-risk Dukes B colorectal cancer by microRNA expression profiling: a preliminary study. Colorectal Dis. 2015; 17(7):578-88. DOI: 10.1111/codi.12886. View

Martin F, OFearraigh C, Hanley C, Curran C, Sweeney K, Kerin M . The prognostic significance of nodal ratio on breast cancer recurrence and its potential for incorporation in a new prognostic index. Breast J. 2013; 19(4):388-93. DOI: 10.1111/tbj.12122. View

La Torre M, Nigri G, Petrucciani N, Cavallini M, Aurello P, Cosenza G . Prognostic assessment of different lymph node staging methods for pancreatic cancer with R0 resection: pN staging, lymph node ratio, log odds of positive lymph nodes. Pancreatology. 2014; 14(4):289-94. DOI: 10.1016/j.pan.2014.05.794. View

Axelsson C, Mouridsen H, Zedeler K . Axillary dissection of level I and II lymph nodes is important in breast cancer classification. The Danish Breast Cancer Cooperative Group (DBCG). Eur J Cancer. 1992; 28A(8-9):1415-8. DOI: 10.1016/0959-8049(92)90534-9. View

Al-Shibli K, Mohammed H, Mikalsen K . Sentinel lymph nodes and breast carcinoma: analysis of 70 cases by frozen section. Ann Saudi Med. 2005; 25(2):111-4. PMC: 6147972. DOI: 10.5144/0256-4947.2005.111. View

de Boer M, van Deurzen C, van Dijck J, Borm G, van Diest P, Adang E . Micrometastases or isolated tumor cells and the outcome of breast cancer. N Engl J Med. 2009; 361(7):653-63. DOI: 10.1056/NEJMoa0904832. View

Arslan N, Sokmen S, Canda A, Terzi C, Sarioglu S . The prognostic impact of the log odds of positive lymph nodes in colon cancer. Colorectal Dis. 2014; 16(11):O386-92. DOI: 10.1111/codi.12702. View

Schiffman S, McMasters K, Scoggins C, Martin R, Chagpar A . Lymph node ratio: a proposed refinement of current axillary staging in breast cancer patients. J Am Coll Surg. 2011; 213(1):45-52. DOI: 10.1016/j.jamcollsurg.2011.04.024. View

10.

Pages F, Galon J, Fridman W . The essential role of the in situ immune reaction in human colorectal cancer. J Leukoc Biol. 2008; 84(4):981-7. DOI: 10.1189/jlb.1107773. View

11.

Tausch C, Taucher S, Dubsky P, Seifert M, Reitsamer R, Kwasny W . Prognostic value of number of removed lymph nodes, number of involved lymph nodes, and lymph node ratio in 7502 breast cancer patients enrolled onto trials of the Austrian Breast and Colorectal Cancer Study Group (ABCSG). Ann Surg Oncol. 2011; 19(6):1808-17. DOI: 10.1245/s10434-011-2189-y. View

12.

Fisher B, Bauer M, Wickerham D, Redmond C, Fisher E, CRUZ A . Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. An NSABP update. Cancer. 1983; 52(9):1551-7. DOI: 10.1002/1097-0142(19831101)52:9<1551::aid-cncr2820520902>3.0.co;2-3. View

13.

Vinh-Hung V, Cserni G, Burzykowski T, Van De Steene J, Voordeckers M, Storme G . Effect of the number of uninvolved nodes on survival in early breast cancer. Oncol Rep. 2003; 10(2):363-8. View

14.

Woodward W, Vinh-Hung V, Ueno N, Cheng Y, Royce M, Tai P . Prognostic value of nodal ratios in node-positive breast cancer. J Clin Oncol. 2006; 24(18):2910-6. DOI: 10.1200/JCO.2005.03.1526. View

15.

Aurello P, DAngelo F, Rossi S, Bellagamba R, Cicchini C, Nigri G . Classification of lymph node metastases from gastric cancer: comparison between N-site and N-number systems. Our experience and review of the literature. Am Surg. 2007; 73(4):359-66. View

16.

Chang G, Rodriguez-Bigas M, Skibber J, Moyer V . Lymph node evaluation and survival after curative resection of colon cancer: systematic review. J Natl Cancer Inst. 2007; 99(6):433-41. DOI: 10.1093/jnci/djk092. View

17.

Somner J, Dixon J, Thomas J . Node retrieval in axillary lymph node dissections: recommendations for minimum numbers to be confident about node negative status. J Clin Pathol. 2004; 57(8):845-8. PMC: 1770384. DOI: 10.1136/jcp.2003.015560. View

18.

Kuru B . Prognostic significance of total number of nodes removed, negative nodes removed, and ratio of positive nodes to removed nodes in node positive breast carcinoma. Eur J Surg Oncol. 2006; 32(10):1082-8. DOI: 10.1016/j.ejso.2006.06.005. View

19.

Vinh-Hung V, Nguyen N, Cserni G, Truong P, Woodward W, Verkooijen H . Prognostic value of nodal ratios in node-positive breast cancer: a compiled update. Future Oncol. 2009; 5(10):1585-603. DOI: 10.2217/fon.09.129. View

20.

van Lancker M, Goor C, Sacre R, Lamote J, Van Belle S, De Coene N . Patterns of axillary lymph node metastasis in breast cancer. Am J Clin Oncol. 1995; 18(3):267-72. DOI: 10.1097/00000421-199506000-00016. View