Enhanced Replication of Highly Pathogenic Influenza A(H7N9) Virus in Humans

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2018 Mar 20

PMID 29553313

Citations 26

Authors

Seiya Yamayoshi

Maki Kiso

Atsuhiro Yasuhara

Mutsumi Ito

Yuelong Shu

Yoshihiro Kawaoka

Affiliations

Soon will be listed here.

Abstract

To clarify the threat posed by emergence of highly pathogenic influenza A(H7N9) virus infection among humans, we characterized the viral polymerase complex. Polymerase basic 2-482R, polymerase basic 2-588V, and polymerase acidic-497R individually or additively enhanced virus polymerase activity, indicating that multiple replication-enhancing mutations in 1 isolate may contribute to virulence.

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