What We Do and Do Not Know About Women and Kidney Diseases; Questions Unanswered and Answers Unquestioned: Reflection on World Kidney Day and International Woman's Day

Overview

Journal Can J Kidney Health Dis

Publisher Sage Publications

Date 2018 Mar 20

PMID 29552348

Authors

Giorgina B Piccoli

Mona Alrukhaimi

Zhi-Hong Liu

Elena Zakharova

Adeera Levin

Affiliations

Soon will be listed here.

Abstract

Background: Chronic kidney disease affects approximately 10% of the world's adult population: It is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus giving an occasion to reflect on open questions on the importance of kidney health in women for the present and the future generations.

Objectives: In this review, we summarize some aspects that are unique to women's kidney health, offering an opportunity to reflect on the importance of women's health and specifically their kidney health, on the community, and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly.

Findings: Girls and women, who make up approximately 50% of the world's population, are important contributors to society and their families. Gender differences continue to exist around the world in access to education, medical care, and participation in clinical studies. Pregnancy is not only a unique state for women, offering an opportunity for diagnosis of kidney disease, but also a state where acute and chronic kidney diseases may manifest, and which may impact future generations with respect to kidney health. There are various autoimmune and other conditions that are more likely to impact women with profound consequences for childbearing, and on the fetus. Women have different complications on dialysis than men, and are more likely to be donors than recipients of kidney transplants.

Conclusion: Improving knowledge on women, kidney health, and kidney disease, may be a way to improve outcomes of kidney diseases worldwide.

References

Eckardt K, Coresh J, Devuyst O, Johnson R, Kottgen A, Levey A . Evolving importance of kidney disease: from subspecialty to global health burden. Lancet. 2013; 382(9887):158-69. DOI: 10.1016/S0140-6736(13)60439-0. View

Jim B, Garovic V . Acute Kidney Injury in Pregnancy. Semin Nephrol. 2017; 37(4):378-385. PMC: 5662118. DOI: 10.1016/j.semnephrol.2017.05.010. View

Acharya A . Management of Acute Kidney Injury in Pregnancy for the Obstetrician. Obstet Gynecol Clin North Am. 2016; 43(4):747-765. DOI: 10.1016/j.ogc.2016.07.007. View

Nitsch D, Grams M, Sang Y, Black C, Cirillo M, Djurdjev O . Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis. BMJ. 2013; 346:f324. PMC: 3558410. DOI: 10.1136/bmj.f324. View

Almaani S, Meara A, Rovin B . Update on Lupus Nephritis. Clin J Am Soc Nephrol. 2016; 12(5):825-835. PMC: 5477208. DOI: 10.2215/CJN.05780616. View

Liyanage T, Ninomiya T, Jha V, Neal B, Patrice H, Okpechi I . Worldwide access to treatment for end-stage kidney disease: a systematic review. Lancet. 2015; 385(9981):1975-82. DOI: 10.1016/S0140-6736(14)61601-9. View

Tranquilli A, Dekker G, Magee L, Roberts J, Sibai B, Steyn W . The classification, diagnosis and management of the hypertensive disorders of pregnancy: A revised statement from the ISSHP. Pregnancy Hypertens. 2015; 4(2):97-104. DOI: 10.1016/j.preghy.2014.02.001. View

Mol B, Roberts C, Thangaratinam S, Magee L, de Groot C, Hofmeyr G . Pre-eclampsia. Lancet. 2015; 387(10022):999-1011. DOI: 10.1016/S0140-6736(15)00070-7. View

Weiner D, Tighiouart H, Elsayed E, Griffith J, Salem D, Levey A . The Framingham predictive instrument in chronic kidney disease. J Am Coll Cardiol. 2007; 50(3):217-24. DOI: 10.1016/j.jacc.2007.03.037. View

10.

Piccoli G, Cabiddu G, Attini R, Vigotti F, Maxia S, Lepori N . Risk of Adverse Pregnancy Outcomes in Women with CKD. J Am Soc Nephrol. 2015; 26(8):2011-22. PMC: 4520166. DOI: 10.1681/ASN.2014050459. View

11.

Prakash J, Pant P, Prakash S, Sivasankar M, Vohra R, Doley P . Changing picture of acute kidney injury in pregnancy: Study of 259 cases over a period of 33 years. Indian J Nephrol. 2016; 26(4):262-7. PMC: 4964686. DOI: 10.4103/0971-4065.161018. View

12.

Wide-Swensson D, Strevens H, Willner J . Antepartum percutaneous renal biopsy. Int J Gynaecol Obstet. 2007; 98(2):88-92. DOI: 10.1016/j.ijgo.2007.03.049. View

13.

Marder W, Vinet E, Somers E . Rheumatic autoimmune diseases in women and midlife health. Womens Midlife Health. 2017; 1. PMC: 5444314. DOI: 10.1186/s40695-015-0012-9. View

14.

Petri M . Epidemiology of systemic lupus erythematosus. Best Pract Res Clin Rheumatol. 2002; 16(5):847-58. DOI: 10.1053/berh.2002.0259. View

15.

Josephson M . Transplantation: pregnancy after kidney donation: more questions than answers. Nat Rev Nephrol. 2009; 5(9):495-7. DOI: 10.1038/nrneph.2009.129. View

16.

Kausz A, Obrador G, Arora P, Ruthazer R, Levey A, Pereira B . Late initiation of dialysis among women and ethnic minorities in the United States. J Am Soc Nephrol. 2000; 11(12):2351-2357. DOI: 10.1681/ASN.V11122351. View

17.

Sehgal A . Outcomes of renal replacement therapy among blacks and women. Am J Kidney Dis. 2000; 35(4 Suppl 1):S148-52. DOI: 10.1016/s0272-6386(00)70242-3. View

18.

OGorman N, Wright D, Poon L, Rolnik D, Syngelaki A, De Alvarado M . Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation: comparison with NICE guidelines and ACOG recommendations. Ultrasound Obstet Gynecol. 2017; 49(6):756-760. DOI: 10.1002/uog.17455. View

19.

Depner T . Prescribing hemodialysis: the role of gender. Adv Ren Replace Ther. 2003; 10(1):71-7. DOI: 10.1053/jarr.2003.50007. View

20.

Imbasciati E, Gregorini G, Cabiddu G, Gammaro L, Ambroso G, Del Giudice A . Pregnancy in CKD stages 3 to 5: fetal and maternal outcomes. Am J Kidney Dis. 2007; 49(6):753-62. DOI: 10.1053/j.ajkd.2007.03.022. View