Serum Trace Elements Profile in Graves' Disease Patients with or Without Orbitopathy in Northeast China

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2018 Mar 17

PMID 29546054

Citations 17

Authors

Yongping Liu

Shanshan Liu

Jinyuan Mao

Sichen Piao

Jing Qin

Shiqiao Peng

Xiaochen Xie

Haixia Guan

Yushu Li

Zhongyan Shan

Weiping Teng

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of the present study was to investigate serum trace elements in Graves' disease (GD) patients with or without orbitopathy in Northeast China.

Methods: Patients with newly diagnosed Graves' disease (HyGD) ( = 66), GD patients with euthyroid status or subclinical thyroidism after treatment (EUGD) ( = 55), GO patients with euthyroid status or subclinical thyroidism after treatment (GO) ( = 57), and normal controls (NC) ( = 66) were enrolled in this study. Serum trace elements were measured with ICP-MS.

Results: Serum selenium (Se) levels in EUGD group (median: 7.53 g/dL), HyGD group (median: 6.76 g/dL), and GO group (median: 7.40 g/dL) were significantly lower than those in NC group (median: 9.20 g/dL, all < 0.01). Serum copper (Cu) levels in GO group (median: 95.93 g/dL) were significantly lower than those in the NC group (median: 113.59 g/dL, = 0.015). After being adjusted for multivariables, thyroid-specific antibodies grade was associated with low Se levels. Hyperthyroidism and thyroid-specific antibodies grade were associated with high Cu levels. In addition, orbitopathy was associated with low Cu levels.

Conclusions: Thyroid autoimmunity was associated with low Se levels. Hyperthyroidism and thyroid autoimmunity may be associated with relatively high serum Cu levels. Alternatively, ophthalmopathy may be related to low serum Cu levels.

Citing Articles

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Chen F, Qiu R, Lin Z, Chen J, Liu P, Huang Y Front Nutr. 2024; 11:1432420.

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Sun M, Yan G, Sun S, Li X, Sun W, Wang Y Clin Interv Aging. 2024; 19:1141-1151.

PMID: 38948168 PMC: 11214795. DOI: 10.2147/CIA.S464615.

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