Clinical Significance of U1-RNP Immune Complexes in Mixed Connective Tissue Disease and Systemic Lupus Erythematosus

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 1987 Jan 1

PMID 2954202

Citations 5

Authors

N Negoro

Y Kanayama

T Takeda

K Amatsu

S Koda

Y Inoue

T Kim

M Okamura

T Inoue

Affiliations

Soon will be listed here.

Abstract

We measured U1-RNP: anti-U1-RNP immune complexes (U1-RNP ICs) in patients with mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) to examine the clinical significance of circulating U1-RNP ICs. The level of U1-RNP ICs in 11 patients with MCTD was significantly higher than that in 22 normal subjects and there was a close correlation between the level of U1-RNP ICs and the clinical disease activity index of MCTD. In contrast, the level of U1-RNP ICs in 31 patients with SLE was not significantly higher than that in normal subjects and that was not correlated with the clinical disease activity index of SLE or the renal histologic activity index of lupus nephritis. We conclude that U1-RNP ICs are present in sera of patients with MCTD and SLE, and that the level of U1-RNP ICs may be closely associated with clinical disease activity in patients with MCTD.

Citing Articles

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References

Triolo G, Giardina E, Rinaldi A, BOMPIANI G . IgA- and insulin-containing (C3-fixing) circulating immune complexes in diabetes mellitus. Clin Immunol Immunopathol. 1984; 30(2):169-77. DOI: 10.1016/0090-1229(84)90051-5. View

Kurata N, Hara I, Kinashi M, Akita H, OFUJI T . The correlation of antibodies to nuclear ribonucleoprotein (RNP) and nuclear acidic protein (Sm) with nephritis in patients with systemic lupus erythematosus (SLE). Contrib Nephrol. 1978; 9:17-24. DOI: 10.1159/000401429. View

Hill G, HINGLAIS N, Tron F, Bach J . Systemic lupus erythematosus. Morphologic correlations with immunologic and clinical data at the time of biopsy. Am J Med. 1978; 64(1):61-79. DOI: 10.1016/0002-9343(78)90180-8. View

Theofilopoulos A, Dixon F . The biology and detection of immune complexes. Adv Immunol. 1979; 28:89-220. DOI: 10.1016/s0065-2776(08)60800-7. View

Tan E . Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. Adv Immunol. 1982; 33:167-240. DOI: 10.1016/s0065-2776(08)60836-6. View

Pereira A, Theofilopoulos A, Dixon F . Detection and partial characterization of circulating immune complexes with solid-phase anti-C3. J Immunol. 1980; 125(2):763-70. View

Mattioli M, Reichlin M . Characterization of a soluble nuclear ribonucleoprotein antigen reactive with SLE sera. J Immunol. 1971; 107(5):1281-90. View

Koffler D, Agnello V, Thoburn R, KUNKEL H . Systemic lupus erythematosus: prototype of immune complex nephritis in man. J Exp Med. 1971; 134(3 Pt 2):169s-179s. View

Lerner M, Steitz J . Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1979; 76(11):5495-9. PMC: 411675. DOI: 10.1073/pnas.76.11.5495. View

10.

Decker J, Steinberg A, Reinertsen J, Plotz P, Balow J, Klippel J . NIH conference. Systemic lupus erythematosus: evolving concepts. Ann Intern Med. 1979; 91(4):587-604. DOI: 10.7326/0003-4819-91-4-587. View

11.

Negoro N, Kanayama Y, Takeda T, Koda S, Inoue T . A solid-phase radioimmunoassay for the detection of nRNP immune complexes. J Immunol Methods. 1986; 91(1):83-9. DOI: 10.1016/0022-1759(86)90105-5. View

12.

Conner G, Nelson D, Wisniewolski R, Lahita R, Blobel G, KUNKEL H . Protein antigens of the RNA-protein complexes detected by anti-SM and anti-RNP antibodies found in serum of patients with systemic lupus erythematosus and related disorders. J Exp Med. 1982; 156(5):1475-85. PMC: 2186852. DOI: 10.1084/jem.156.5.1475. View

13.

Cunningham P, Andrews B, Davis 4th J . Immune complexes in progressive systemic sclerosis and mixed connective tissue disease. J Rheumatol. 1980; 7(3):301-8. View

14.

Halla J, Volanakis J, Schrohenloher R . Circulating immune complexes in mixed connective tissue disease. Arthritis Rheum. 1979; 22(5):484-9. DOI: 10.1002/art.1780220507. View

15.

Sharp G, Irvin W, May C, HOLMAN H, MCDUFFIE F, Hess E . Association of antibodies to ribonucleoprotein and Sm antigens with mixed connective-tissue disease, systematic lupus erythematosus and other rheumatic diseases. N Engl J Med. 1976; 295(21):1149-54. DOI: 10.1056/NEJM197611182952101. View

16.

Koffler D, Agnello V, Kimkel H . Polynucleotide immune complexes in serum and glomeruli of patients with systemic lupus erythematosus. Am J Pathol. 1974; 74(1):109-24. PMC: 1910734. View

17.

Maury C, Teppo A . Demonstration of tissue 90 kD glycoprotein as antigen in circulating IgG immune complexes in dermatitis herpetiformis and coeliac disease. Lancet. 1984; 2(8408):892-4. DOI: 10.1016/s0140-6736(84)90654-8. View

18.

Nydegger U, Lambert P, Gerber H, MIESCHER P . Circulating immune complexes in the serum in systemic lupus erythematosus and in carriers of hepatitis B antigen. Quantitation by binding to radiolabeled C1q. J Clin Invest. 1974; 54(2):297-309. PMC: 301557. DOI: 10.1172/JCI107765. View

19.

Tan E, Cohen A, Fries J, MASI A, McShane D, Rothfield N . The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982; 25(11):1271-7. DOI: 10.1002/art.1780251101. View

20.

Hall R, Lawley T . Characterization of circulating and cutaneous IgA immune complexes in patients with dermatitis herpetiformis. J Immunol. 1985; 135(3):1760-5. View