Oral Health-related Quality of Life is Associated with Disease Specific Parameters in Patients with Ankylosing Spondylitis

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2018 Mar 16

PMID 29541915

Citations 7

Authors

Gerhard Schmalz

Donya Douglas

David Douglas

Susann Patschan

Daniel Patschan

Gerhard A Muller

Rainer Haak

Jan Schmickler

Dirk Ziebolz

Affiliations

Soon will be listed here.

Abstract

Background: The aim of this cross-sectional study was to investigate oral health-related quality of life (OHRQoL) in patients with ankylosing spondylitis (AS) and its association to oral health as well as AS specific parameters.

Methods: Patients with AS and a healthy control group (HC) were included and examined. The oral examination included decayed-, missing-, and filled-teeth index (DMF-T) as well as assessment of periodontal probing depth and clinical attachment loss to classify patients into healthy/mild, moderate, or severe periodontitis. Furthermore, the German short form of the oral health impact profile (OHIP G14) was used.

Results: A total of 50 patients each group (age: AS, 47.18 ± 15.67; HC, 55.82 ± 10.56; p < 0.01, gender male: AS, 52%; HC, 46%; p = 0.69) was included. AS patients showed worse D-T (p < 0.01) and periodontal condition (p = 0.01). The OHIP G14 score was clinically relevant and statistically significant higher in AS compared to HC (AS, 6.2 [2; 0-10.75]; HC, 1.7 [0; 0-2.0]; < 0.01). Only in HC, an association of OHIP G14 to DMF-T (p = 0.01) and M-T (p = 0.01) was found, while the OHIP G14 in AS group was not associated to oral health parameters. Within the AS group, the majority of investigated AS specific parameters were statistically significant and clinically relevant associated to OHIP G14 scores (p < 0.05).

Conclusion: Patients with AS show worse OHRQoL compared to HC, irrespective of oral status. The high general disease burden might affect OHRQoL, making an increased attention of these patients in dental care, especially considering psychological aspects, necessary.

Clinical Relevance: Increased consideration of psychosocial and disease related aspects in dental care of AS patients appear recommendable.

Citing Articles

Oral manifestations associated with inflammatory bowel disease and early endoscopic findings in patients with spondyloarthritis.

Alvarado-Julio A, Chumacero-Palma K, Buenahora M, Parra-Izquierdo V, Monsalve M, Torres A BMC Oral Health. 2022; 22(1):477.

PMID: 36348398 PMC: 9644594. DOI: 10.1186/s12903-022-02497-4.

The Salivary Microbiota, Cytokines, and Metabolome in Patients with Ankylosing Spondylitis Are Altered and More Proinflammatory than Those in Healthy Controls.

Lv L, Jiang H, Yan R, Xu D, Wang K, Wang Q mSystems. 2021; 6(3):e0117320.

PMID: 34156295 PMC: 8269253. DOI: 10.1128/mSystems.01173-20.

Periodontal diseases and its association with disease activity in ankylosing spondylitis/SpA: A systematic review.

Pandey A, Rajak R, Pandey M Eur J Rheumatol. 2020; 8(3):168-179.

PMID: 33284102 PMC: 9770410. DOI: 10.5152/eurjrheum.2020.20177.

Four-dimensional oral health-related quality of life impact in children: A systematic review.

Omara M, Stamm T, Bekes K J Oral Rehabil. 2020; 48(3):293-304.

PMID: 32757443 PMC: 7984176. DOI: 10.1111/joor.13066.

Schmalz G, Busjan R, Dietl M, Hasenkamp J, Trumper L, Ziebolz D Oral Health Prev Dent. 2020; 18(3):461-466.

PMID: 32515417 PMC: 11654584. DOI: 10.3290/j.ohpd.a44685.

References

Agrawal N, Agarwal K, Varshney A, Agrawal N, Dubey A . Is there a common pathogenesis in aggressive periodontitis & ankylosing spondylitis in HLA-B27 patient?. Med Hypotheses. 2016; 90:63-5. DOI: 10.1016/j.mehy.2016.03.005. View

John M, Rener-Sitar K, Baba K, Celebic A, Larsson P, Szabo G . Patterns of impaired oral health-related quality of life dimensions. J Oral Rehabil. 2016; 43(7):519-27. PMC: 4902736. DOI: 10.1111/joor.12396. View

Haywood K, Packham J, Jordan K . Assessing fatigue in ankylosing spondylitis: the importance of frequency and severity. Rheumatology (Oxford). 2013; 53(3):552-6. DOI: 10.1093/rheumatology/ket397. View

Meesters J, Bremander A, Bergman S, Petersson I, Turkiewicz A, Englund M . The risk for depression in patients with ankylosing spondylitis: a population-based cohort study. Arthritis Res Ther. 2014; 16(5):418. PMC: 4180137. DOI: 10.1186/s13075-014-0418-z. View

Visscher C, Lobbezoo F, Schuller A . Dental status and oral health-related quality of life. A population-based study. J Oral Rehabil. 2014; 41(6):416-22. DOI: 10.1111/joor.12167. View

Reissmann D, John M, Schierz O, Kriston L, Hinz A . Association between perceived oral and general health. J Dent. 2013; 41(7):581-9. DOI: 10.1016/j.jdent.2013.05.007. View

Mendez M, Melchiors Angst P, Stadler A, Oppermann R, Gomes S . Impacts of supragingival and subgingival periodontal treatments on oral health-related quality of life. Int J Dent Hyg. 2016; 15(2):135-141. DOI: 10.1111/idh.12193. View

Bedaiwi M, Sari I, Thavaneswaran A, Ayearst R, Haroon N, Inman R . Fatigue in Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Analysis from a Longitudinal Observation Cohort. J Rheumatol. 2015; 42(12):2354-60. DOI: 10.3899/jrheum.150463. View

Sezer U, Erciyas K, Pehlivan Y, Ustun K, Tarakcioglu M, Senyurt S . Serum cytokine levels and periodontal parameters in ankylosing spondylitis. J Periodontal Res. 2011; 47(3):396-401. DOI: 10.1111/j.1600-0765.2011.01448.x. View

10.

Ratz T, Dean L, Atzeni F, Reeks C, Macfarlane G, Macfarlane T . A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis. Rheumatology (Oxford). 2014; 54(3):500-10. DOI: 10.1093/rheumatology/keu356. View

11.

Page R, Eke P . Case definitions for use in population-based surveillance of periodontitis. J Periodontol. 2007; 78(7 Suppl):1387-99. DOI: 10.1902/jop.2007.060264. View

12.

van der Linden S, VALKENBURG H, Cats A . Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984; 27(4):361-8. DOI: 10.1002/art.1780270401. View

13.

Durham J, Fraser H, McCracken G, Stone K, John M, Preshaw P . Impact of periodontitis on oral health-related quality of life. J Dent. 2013; 41(4):370-6. DOI: 10.1016/j.jdent.2013.01.008. View

14.

Braun J, Sieper J . Ankylosing spondylitis. Lancet. 2007; 369(9570):1379-1390. DOI: 10.1016/S0140-6736(07)60635-7. View

15.

Slade G, Spencer A . Development and evaluation of the Oral Health Impact Profile. Community Dent Health. 1994; 11(1):3-11. View

16.

Schmalz G, Wendorff H, Marcinkowski A, Weinreich G, Teschler H, Haak R . Oral health related quality of life depending on oral health and specific factors in patients after lung transplantation. Clin Respir J. 2017; 12(2):731-737. DOI: 10.1111/crj.12625. View

17.

Liu L, Xiao W, He Q, Jiang W . Generic and oral quality of life is affected by oral mucosal diseases. BMC Oral Health. 2012; 12:2. PMC: 3280167. DOI: 10.1186/1472-6831-12-2. View

18.

Muhlberg S, Jager J, Krohn-Grimberghe B, Patschan S, Mausberg R, Schmalz G . Oral health-related quality of life depending on oral health in patients with rheumatoid arthritis. Clin Oral Investig. 2017; 21(9):2661-2670. DOI: 10.1007/s00784-017-2068-4. View

19.

Blaizot A, Monsarrat P, Constantin A, Vergnes J, Fernandez De Grado G, Nabet C . Oral health-related quality of life among outpatients with rheumatoid arthritis. Int Dent J. 2013; 63(3):145-53. PMC: 9374943. DOI: 10.1111/idj.12023. View

20.

Fabri G, Pereira R, Savioli C, Saad C, de Moraes J, Siqueira J . Periodontitis Response to Anti-TNF Therapy in Ankylosing Spondylitis. J Clin Rheumatol. 2015; 21(7):341-5. DOI: 10.1097/RHU.0000000000000300. View