Serial Assessment of Endothelial Function 1, 6, and 12 months After ST-elevation Myocardial Infarction

Overview

Journal Heart Vessels

Specialty Cardiology & Vascular Diseases

Date 2018 Mar 16

PMID 29541845

Authors

Jasveen J Kandhai-Ragunath

Carine J M Doggen

Liefke C van der Heijden

Marlies M Kok

Paolo Zocca

Bjorn de Wagenaar

Cees Doelman

Harald T Jorstad

Ron J G Peters

Clemens von Birgelen

Affiliations

Soon will be listed here.

Abstract

Knowledge about the changes in endothelial function after ST-elevation myocardial infarction (STEMI) is of substantial interest, but serial data are scarce. The aim of the present study was to noninvasively evaluate whether endothelial function, as assessed shortly after primary percutaneous coronary intervention (PPCI) for STEMI, may improve until 12-month follow-up. This prospective observational cohort study was performed in patients in the RESPONSE randomized trial who participated in a substudy and underwent noninvasive assessment of endothelial function at 1 (baseline), 6, and 12-month follow-up after treatment of a STEMI by PPCI. The reactive hyperemia peripheral artery tonometry (RH-PAT) method was used to assess endothelial function (higher RH-PAT index signifies better function). Of the 70 study participants, who were 57.4 ± 9.7 years of age, 55 (78.6%) were male and 9 (13%) had diabetes. The endothelial function deteriorated significantly during follow-up: the RH-PAT index at baseline, 6, and 12-month follow-up was 1.90 ± 0.58, 1.81 ± 0.57, and 1.69 ± 0.49, respectively (p = 0.04). Although patients were carefully treated in outpatient clinics and adequate pharmacological therapy was prescribed, we noted an increase in total cholesterol (p = 0.001), LDL cholesterol (p = 0.002), HbA1C (p = 0.054), and diastolic blood pressure (p = 0.047) However, multivariate analysis revealed that this increase in cardiovascular risk factors could not explain the observed deterioration in endothelial function. In patients with STEMI, we observed a significant deterioration in endothelial function during 12 months after PPCI that could not be explained by changes in the traditional cardiovascular risk profile.

References

Muscogiuri G, Annweiler C, Duval G, Karras S, Tirabassi G, Salvio G . Vitamin D and cardiovascular disease: From atherosclerosis to myocardial infarction and stroke. Int J Cardiol. 2017; 230:577-584. DOI: 10.1016/j.ijcard.2016.12.053. View

Kandhai-Ragunath J, Jorstad H, de Wagenaar B, de Man F, Stoel M, van Es J . Assessment of the relation between initial culprit vessel patency in acute ST-elevation myocardial infarction and endothelial function. EuroIntervention. 2014; 10(7):784-91. DOI: 10.4244/EIJV10I7A137. View

Sakabe K, Fukuda N, Wakayama K, Nada T, Shinohara H, Tamura Y . Time course differences for statin-induced pleiotropic effects in hypercholesterolemic patients. Int J Cardiol. 2004; 94(1):111-7. DOI: 10.1016/j.ijcard.2003.08.001. View

Jorstad H, von Birgelen C, Alings A, Liem A, van Dantzig J, Jaarsma W . Effect of a nurse-coordinated prevention programme on cardiovascular risk after an acute coronary syndrome: main results of the RESPONSE randomised trial. Heart. 2013; 99(19):1421-30. PMC: 3786610. DOI: 10.1136/heartjnl-2013-303989. View

Careri G, Nerla R, Di Monaco A, Russo G, Stazi A, Villano A . Clinical correlates and prognostic value of flow mediated dilation in patients with non-ST segment elevation acute coronary syndromes. Am J Cardiol. 2012; 111(1):51-7. DOI: 10.1016/j.amjcard.2012.08.049. View

Anderson T, Uehata A, Gerhard M, Meredith I, Knab S, Delagrange D . Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol. 1995; 26(5):1235-41. DOI: 10.1016/0735-1097(95)00327-4. View

Cannon C, Steinberg B, Murphy S, Mega J, Braunwald E . Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy. J Am Coll Cardiol. 2006; 48(3):438-45. DOI: 10.1016/j.jacc.2006.04.070. View

Takishima I, Nakamura T, Hirano M, Kitta Y, Kobayashi T, Fujioka D . Predictive value of serial assessment of endothelial function in chronic heart failure. Int J Cardiol. 2011; 158(3):417-22. DOI: 10.1016/j.ijcard.2011.01.059. View

Hasdai D, Gibbons R, Holmes Jr D, Higano S, Lerman A . Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation. 1997; 96(10):3390-5. DOI: 10.1161/01.cir.96.10.3390. View

10.

Targonski P, Bonetti P, Pumper G, Higano S, Holmes Jr D, Lerman A . Coronary endothelial dysfunction is associated with an increased risk of cerebrovascular events. Circulation. 2003; 107(22):2805-9. DOI: 10.1161/01.CIR.0000072765.93106.EE. View

11.

Latsios G, Antonopoulos A, Oikonomou E, Mourouzis K, Giannaki A, Papamikroulis A . Effects of transradial coronary catheterization on systemic and local vascular endothelial function and inflammatory process. Int J Cardiol. 2016; 223:109-110. DOI: 10.1016/j.ijcard.2016.08.188. View

12.

Bonetti P, Pumper G, Higano S, Holmes Jr D, Kuvin J, Lerman A . Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol. 2004; 44(11):2137-41. DOI: 10.1016/j.jacc.2004.08.062. View

13.

Sposito A, Santos S, de Faria E, Abdalla D, da Silva L, Soares A . Timing and dose of statin therapy define its impact on inflammatory and endothelial responses during myocardial infarction. Arterioscler Thromb Vasc Biol. 2011; 31(5):1240-6. DOI: 10.1161/ATVBAHA.110.218685. View

14.

Takayama T, Hiro T, Yoda S, Fukamachi D, Haruta H, Kogo T . Effect of Aggressive lipid-lowering treatment with Rosuvastatin on vascular endoTHelium function: evaluation of vascular endothelium function (EARTH study). Heart Vessels. 2017; 33(6):590-594. DOI: 10.1007/s00380-017-1094-0. View

15.

Blum A, Schneider D, Sobel B, Dauerman H . Endothelial dysfunction and inflammation after percutaneous coronary intervention. Am J Cardiol. 2004; 94(11):1420-3. DOI: 10.1016/j.amjcard.2004.07.146. View

16.

Kitta Y, Obata J, Nakamura T, Hirano M, Kodama Y, Fujioka D . Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease. J Am Coll Cardiol. 2009; 53(4):323-30. DOI: 10.1016/j.jacc.2008.08.074. View

17.

Solheim S, Grogaard H, Hoffmann P, Arnesen H, Seljeflot I . Inflammatory responses after percutaneous coronary intervention in patients with acute myocardial infarction or stable angina pectoris. Scand J Clin Lab Invest. 2009; 68(7):555-62. DOI: 10.1080/00365510701884584. View

18.

Schroeder S, Enderle M, Ossen R, Meisner C, Baumbach A, Pfohl M . Noninvasive determination of endothelium-mediated vasodilation as a screening test for coronary artery disease: pilot study to assess the predictive value in comparison with angina pectoris, exercise electrocardiography, and myocardial perfusion.... Am Heart J. 1999; 138(4 Pt 1):731-9. DOI: 10.1016/s0002-8703(99)70189-4. View

19.

Brown B, Zhao X, Sacco D, Albers J . Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation. 1993; 87(6):1781-91. DOI: 10.1161/01.cir.87.6.1781. View

20.

Widlansky M, Gokce N, Keaney Jr J, Vita J . The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003; 42(7):1149-60. DOI: 10.1016/s0735-1097(03)00994-x. View