Altered Peripheral Amino Acid Profile Indicate a Systemic Impact of Active Celiac Disease and a Possible Role of Amino Acids in Disease Pathogenesis

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2018 Mar 15

PMID 29538446

Citations 7

Authors

Asa Torinsson Naluai

Ladan Saadat Vafa

Audur H Gudjonsdottir

Henrik Arnell

Lars Browaldh

Staffan Nilsson

Daniel Agardh

Affiliations

Soon will be listed here.

Abstract

Background: We have previously performed a Genome Wide Association and linkage study that indicated a new disease triggering mechanism involving amino acid metabolism and nutrient sensing signaling pathways.

Objective: The aim of this study was to investigate if plasma amino acid levels differed among children with celiac disease compared with disease controls.

Materials And Methods: Fasting plasma samples from 141 children with celiac disease and 129 non-celiac disease controls, were analyzed for amino acid levels by liquid chromatography-tandem mass spectrometry (LC/MS). A general linear model using age and experimental effects as covariates was used to compare amino acid levels between children with a diagnosis of celiac disease and controls.

Results: Seven out of twenty-three analyzed amino acids were elevated in children with celiac disease compared with controls (tryptophan, taurine, glutamic acid, proline, ornithine, alanine and methionine). The significance of the individual amino acids do not survive multiple correction, however, multivariate analyses of the amino acid profile showed significantly altered amino acid levels in children with celiac disease overall and after correction for age, sex and experimental effects (p = 8.4 × 10-8).

Conclusion: These findings support the idea that amino acids could influence systemic inflammation and play a possible role in disease pathogenesis.

Citing Articles

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Proteomic analysis of plasma and duodenal tissue in celiac disease patients reveals potential noninvasive diagnostic biomarkers.

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Investigating the Impact of Vitamin A and Amino Acids on Immune Responses in Celiac Disease Patients.

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Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease.

Karlson O, Arnell H, Gudjonsdottir A, Agardh D, Torinsson Naluai A BMC Med. 2022; 20(1):440.

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