Molecular Diagnosis of Felis Catus Gammaherpesvirus 1 (FcaGHV1) Infection in Cats of Known Retrovirus Status with and Without Lymphoma

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2018 Mar 15

PMID 29538321

Citations 16

Authors

Alicia J McLuckie

Vanessa R Barrs

Scott Lindsay

Mahdis Aghazadeh

Cheryl Sangster

Julia A Beatty

Affiliations

Soon will be listed here.

Abstract

The pathogenicity of gammaherpesvirus 1 (FcaGHV1), a common infection of domestic cats, is unknown. To explore an association between FcaGHV1 detection and feline lymphoma, a retrospective, cross-sectional, disease-association study was conducted. The infection status of all cats for feline immunodeficiency virus and feline leukaemia virus was determined. Neither a molecular diagnosis of FcaGHV1 nor whole-blood FcaGHV1 load was related to outcome in 122 lymphoma cases compared with 71 controls matched for age and sex. Molecular analysis of lymphoma-derived DNA paired with autologous uninvolved tissue did not suggest restriction of FcaGHV1 DNA to tumour tissue. FcaGHV1 DNA detection was associated with significantly shorter survival in lymphoma cases, an observation that could not be adequately explained by treatment differences. In addition, regressive feline leukaemia virus infection was identified as a risk factor for lymphoma. A history of fighting or roaming was identified as a novel epidemiological risk factor for FcaGHV1 detection, lending support to intercat aggression as a potential route of transmission. Studies investigating the cellular location and expression of FcaGHV1 are indicated to assist in ruling out a lymphomagenic role for this virus. Prospective investigation of FcaGHV1 DNA detection as a prognostic marker in feline lymphoma is warranted.

Citing Articles

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References

Ho M, Miller G, ATCHISON R, BREINIG M, Dummer J, Andiman W . Epstein-Barr virus infections and DNA hybridization studies in posttransplantation lymphoma and lymphoproliferative lesions: the role of primary infection. J Infect Dis. 1985; 152(5):876-86. PMC: 3154749. DOI: 10.1093/infdis/152.5.876. View

Neil J, Hughes D, McFarlane R, Wilkie N, Onions D, Lees G . Transduction and rearrangement of the myc gene by feline leukaemia virus in naturally occurring T-cell leukaemias. Nature. 1984; 308(5962):814-20. DOI: 10.1038/308814a0. View

Louwerens M, London C, Pedersen N, Lyons L . Feline lymphoma in the post-feline leukemia virus era. J Vet Intern Med. 2005; 19(3):329-35. DOI: 10.1892/0891-6640(2005)19[329:flitpl]2.0.co;2. View

Gartner B, Preiksaitis J . EBV viral load detection in clinical virology. J Clin Virol. 2010; 48(2):82-90. DOI: 10.1016/j.jcv.2010.03.016. View

Lankester F, Lugelo A, Kazwala R, Keyyu J, Cleaveland S, Yoder J . The economic impact of malignant catarrhal fever on pastoralist livelihoods. PLoS One. 2015; 10(1):e0116059. PMC: 4309580. DOI: 10.1371/journal.pone.0116059. View

Englert T, Lutz H, Sauter-Louis C, Hartmann K . Survey of the feline leukemia virus infection status of cats in Southern Germany. J Feline Med Surg. 2012; 14(6):392-8. PMC: 10822583. DOI: 10.1177/1098612X12440531. View

Swerdlow S, Campo E, Pileri S, Lee Harris N, Stein H, Siebert R . The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016; 127(20):2375-90. PMC: 4874220. DOI: 10.1182/blood-2016-01-643569. View

Sarid R, Gao S . Viruses and human cancer: from detection to causality. Cancer Lett. 2010; 305(2):218-27. PMC: 3037427. DOI: 10.1016/j.canlet.2010.09.011. View

Westman M, Paul A, Malik R, McDonagh P, Ward M, Hall E . Seroprevalence of feline immunodeficiency virus and feline leukaemia virus in Australia: risk factors for infection and geographical influences (2011-2013). JFMS Open Rep. 2017; 2(1):2055116916646388. PMC: 5362860. DOI: 10.1177/2055116916646388. View

10.

Hoffmann-Fezer G, Thum J, Ackley C, Herbold M, Mysliwietz J, Thefeld S . Decline in CD4+ cell numbers in cats with naturally acquired feline immunodeficiency virus infection. J Virol. 1992; 66(3):1484-8. PMC: 240873. DOI: 10.1128/JVI.66.3.1484-1488.1992. View

11.

Fan H, Kim S, Chima C, Israel B, Lawless K, Eagan P . Epstein-Barr viral load as a marker of lymphoma in AIDS patients. J Med Virol. 2004; 75(1):59-69. DOI: 10.1002/jmv.20238. View

12.

Parkin D . The global health burden of infection-associated cancers in the year 2002. Int J Cancer. 2006; 118(12):3030-44. DOI: 10.1002/ijc.21731. View

13.

Stutzer B, Simon K, Lutz H, Majzoub M, Hermanns W, Hirschberger J . Incidence of persistent viraemia and latent feline leukaemia virus infection in cats with lymphoma. J Feline Med Surg. 2010; 13(2):81-7. PMC: 10822315. DOI: 10.1016/j.jfms.2010.09.015. View

14.

Gabor L, Canfield P, Malik R . Immunophenotypic and histological characterisation of 109 cases of feline lymphosarcoma. Aust Vet J. 1999; 77(7):436-41. DOI: 10.1111/j.1751-0813.1999.tb12085.x. View

15.

Collette S, Allstadt S, Chon E, Vernau W, Smith A, Garrett L . Treatment of feline intermediate- to high-grade lymphoma with a modified university of Wisconsin-Madison protocol: 119 cases (2004-2012). Vet Comp Oncol. 2015; 14 Suppl 1:136-46. PMC: 5012421. DOI: 10.1111/vco.12158. View

16.

Beatty J, Tasker S, Jarrett O, Lam A, Gibson S, Noe-Nordberg A . Markers of feline leukaemia virus infection or exposure in cats from a region of low seroprevalence. J Feline Med Surg. 2011; 13(12):927-33. PMC: 10832971. DOI: 10.1016/j.jfms.2011.07.011. View

17.

DORN C, Taylor D, Schneider R, Hibbard H, Klauber M . Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst. 1968; 40(2):307-18. View

18.

Tateno M, Takahashi M, Miyake E, Nishigaki K, Tsujimoto H, Endo Y . Molecular epidemiological study of gammaherpesvirus in domestic cats in Japan. J Vet Med Sci. 2017; 79(10):1735-1740. PMC: 5658569. DOI: 10.1292/jvms.17-0039. View

19.

Kidney B, Ellis J, Haines D, Jackson M . Evaluation of formalin-fixed paraffin-embedded tissues obtained from vaccine site-associated sarcomas of cats for DNA of feline immunodeficiency virus. Am J Vet Res. 2000; 61(9):1037-41. DOI: 10.2460/ajvr.2000.61.1037. View

20.

Luria B, Levy J, Lappin M, Breitschwerdt E, Legendre A, Hernandez J . Prevalence of infectious diseases in feral cats in Northern Florida. J Feline Med Surg. 2004; 6(5):287-96. PMC: 7128492. DOI: 10.1016/j.jfms.2003.11.005. View