Circulating MicroRNA-196a is an Early Gastric Cancer Biomarker

Overview

Journal Oncotarget

Specialty Oncology

Date 2018 Mar 15

PMID 29535809

Citations 10

Authors

Tsung-Hsing Chen

Chieh Lee

Cheng-Tang Chiu

Yin-Yi Chu

Hao-Tsai Cheng

Jun-Te Hsu

Yung-Kuan Tsou

Ren-Chin Wu

Tse-Ching Chen

Nien-Chen Chang

Ta-Sen Yeh

Kwang-Huei Lin

Affiliations

Soon will be listed here.

Abstract

MicroRNA-196a (miRNA-196a) is associated with the development of gastric cancer and metastasis. Intestinal metaplasia and low- or high-grade dysplasia are considered to be precursors of intestinal type gastric cancer. Accordingly, we investigated the expression of plasma miRNA-196a as an early detection biomarker in precancerous gastric lesions and early cancer (pT1a/b), which is otherwise treated with endoscopic submucosal dissection. Our data showed that levels of circulating (plasma) miRNA-196a were higher in patients with precancerous lesions/early gastric adenocarcinoma than in healthy controls. The area under the receiver operating characteristic curve (AUC) for healthy controls vs. intestinal metaplasia was 0.9736; healthy controls vs. low-grade/high-grade dysplasia 0.9495; and healthy controls vs. early gastric cancer 0.9318. These results indicate that circulating miRNA-196a is a novel biomarker for detection of early gastric cancer and its precursor.

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