Infants Born Large for Gestational Age and Developmental Attainment in Early Childhood

Overview

Journal Int J Pediatr

Publisher Wiley

Specialty Pediatrics

Date 2018 Mar 15

PMID 29535788

Citations 2

Authors

Cairina E Frank

Kathy N Speechley

Jennifer J Macnab

M Karen Campbell

Affiliations

Soon will be listed here.

Abstract

Objectives: To investigate if an association exists between being born large for gestational age (LGA) and verbal ability or externalizing behaviour problems at ages 4-5 years.

Method: A secondary analysis was conducted using the National Longitudinal Survey of Children and Youth, including singleton births in 2004-2005 followed till 4-5 years ( = 1685). LGA was defined as a birth weight > 90th percentile. Outcomes included poor verbal ability (scoring < 15th percentile on the Revised Peabody Picture Vocabulary Test) and externalizing behaviour problems (scoring > 90th percentile on externalizing behaviour scales). Multivariable logistic regression with longitudinal standardized funnel weights and bootstrapping estimation were used.

Results: Infants born LGA were not found to be at increased risk for poor verbal ability (aOR: 1.16 [0.49,2.72] and aOR: 0.83 [0.37,1.87] for girls and boys, resp.) or externalizing behaviour problems (aOR: 1.24 [0.52,2.93] and aOR: 1.24 [0.66,2.36] for girls and boys, resp.). Social factors were found to impact developmental attainment. Maternal smoking led to an increased risk for externalizing behaviour problems (aOR: 3.33 [1.60,6.94] and aOR: 2.12 [1.09,4.13] for girls and boys, resp.).

Conclusion: There is no evidence to suggest that infants born LGA are at increased risk for poor verbal ability or externalizing behaviour problems.

Citing Articles

Cognitive and academic outcomes of large-for-gestational-age babies born at early term: A systematic review and meta-analysis.

Zhao X, Poskett A, Stracke M, Quenby S, Wolke D Acta Obstet Gynecol Scand. 2024; 104(2):288-301.

PMID: 39475202 PMC: 11782071. DOI: 10.1111/aogs.15001.

Association of birthweight centiles and early childhood development of singleton infants born from 37 weeks of gestation in Scotland: A population-based cohort study.

Adanikin A, Lawlor D, Pell J, Nelson S, Smith G, Iliodromiti S PLoS Med. 2022; 19(10):e1004108.

PMID: 36219591 PMC: 9553050. DOI: 10.1371/journal.pmed.1004108.

Risk of intellectual disability in children born appropriate-for-gestational-age at term or post-term: impact of birth weight for gestational age and gestational age.

Chen R, Tedroff K, Villamor E, Lu D, Cnattingius S Eur J Epidemiol. 2019; 35(3):273-282.

PMID: 31788734 PMC: 7154017. DOI: 10.1007/s10654-019-00590-7.

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