Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Mar 14

PMID 29534010

Citations 23

Authors

Han Gao

Gang Li

Hong-Xiang Lou

Affiliations

Soon will be listed here.

Abstract

Exploration of structurally novel natural products greatly facilitates the discovery of biologically active pharmacophores that are biologically validated starting points for the development of new drugs. Endophytes that colonize the internal tissues of plant species, have been proven to produce a large number of structurally diverse secondary metabolites. These molecules exhibit remarkable biological activities, including antimicrobial, anticancer, anti-inflammatory and antiviral properties, to name but a few. This review surveys the structurally diverse natural products with new carbon skeletons, unusual ring systems, or rare structural moieties that have been isolated from endophytes between 1996 and 2016. It covers their structures and bioactivities. Biosynthesis and/or total syntheses of some important compounds are also highlighted. Some novel secondary metabolites with marked biological activities might deserve more attention from chemists and biologists in further studies.

Citing Articles

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Cheng Y, Zhang X, Zhang W, Dong J, Ma Y, Zhang A Microorganisms. 2025; 13(2).

PMID: 40005782 PMC: 11858288. DOI: 10.3390/microorganisms13020417.

MACROLACTONES AND MACROLIDES FROM PLANT ENDOPHYTIC FUNGI, CHEMICAL SCAFFOLDS, BIOLOGICAL ACTIVITIES AND SPECTROSCOPY: A COMPREHENSIVE REVIEW.

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Exploring the antioxidant potential of endophytic fungi: a review on methods for extraction and quantification of total antioxidant capacity (TAC).

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