Targeting Gut Microbiota in Hepatocellular Carcinoma: Probiotics As a Novel Therapy

Overview

Journal Hepatobiliary Surg Nutr

Publisher AME Publishing Company

Date 2018 Mar 14

PMID 29531939

Citations 46

Authors

Murphy L Y Wan

Hani El-Nezami

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC), the most common primary liver cancer, is one of the dreaded complications of chronic liver disease. Recent experimental and clinical studies have revealed that the alteration of gut-liver axis plays a pivotal role in the onset of chronic liver diseases, including HCC. Altered gut microbiota and endotoxemia are increasingly recognized as critical components in promoting the progression of chronic liver diseases to HCC. Probiotics have been suggested as a novel, safe and cost-effective approach to prevent or treat HCC. Mechanisms by which probiotics exerts their anti-cancer effects include their ability to bind carcinogens, modulation of gut microbiota, improvement of intestinal barrier function, and immunomodulation. This review summarizes the literature findings of the changes in gut microbiota linked to HCC, and discusses the possible therapeutic implications of probiotics for HCC.

Citing Articles

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Modulation of gut microbiota by probiotics to improve the efficacy of immunotherapy in hepatocellular carcinoma.

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Microbiota and Gut-Liver Axis: An Unbreakable Bond?.

Sivaprasadan S, Anila K, Nair K, Mallick S, Biswas L, Valsan A Curr Microbiol. 2024; 81(7):193.

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