Transcriptional Landscape of Human Endogenous Retroviruses (HERVs) and Other Repetitive Elements in Psoriatic Skin

Overview

Journal Sci Rep

Specialty Science

Date 2018 Mar 14

PMID 29531256

Citations 9

Authors

Freddy Lattekivi

Sulev Koks

Maris Keermann

Ene Reimann

Ele Prans

Kristi Abram

Helgi Silm

Gea Koks

Kulli Kingo

Affiliations

Soon will be listed here.

Abstract

Human endogenous retrovirus (HERV) sequences make up at least 8% of the human genome. Transcripts originating from these loci as well as proteins encoded by them have been detected in various tissues. HERVs are believed to be implicated in autoimmune diseases, however the extent to which, has remained unclear. Differential expression studies have so far been limited to certain HERV subfamilies with conserved sequences. No studies have been published describing the genome-wide expression pattern of HERVs and repetitive elements in the context of psoriasis. In the present study, we analysed total RNA sequencing data from skin samples of 12 psoriasis patients and 12 healthy controls, which enabled us to describe the entire transcriptional landscape of repetitive elements. We report high levels of repetitive element expression in the skin of psoriasis patients as well as healthy controls. The majority of differentially expressed elements were downregulated in lesional and non-lesional skin, suggesting active HERV suppression in the pro-inflammatory environment of psoriatic skin. However, we also report upregulation of a small subset of HERVs previously described in the context of autoimmune diseases, such as members of the HERV-K and W families, with the potential to affect the immunopathogenesis of psoriasis.

Citing Articles

Human Endogenous Retroviruses Expression in Autoimmunity.

Viret C, Bynoe M Yale J Biol Med. 2024; 97(4):521-528.

PMID: 39703611 PMC: 11650914. DOI: 10.59249/OIKF8301.

Transcriptional Landscape of Repetitive Elements in Psoriatic Skin from Large Cohort Studies: Relevance to Psoriasis Pathophysiology.

Krishnan V, Koks S Int J Mol Sci. 2023; 24(23).

PMID: 38069048 PMC: 10706217. DOI: 10.3390/ijms242316725.

A novel colony-stimulating factor 1 (CSF1) translocation involving human endogenous retroviral element in a tenosynovial giant cell tumor.

Lipplaa A, Meijer D, van de Sande M, Gelderblom H, Bovee J, Mei H Genes Chromosomes Cancer. 2022; 62(4):223-230.

PMID: 36504457 PMC: 10108088. DOI: 10.1002/gcc.23116.

Expression Quantitative Trait Loci (eQTLs) Associated with Retrotransposons Demonstrate their Modulatory Effect on the Transcriptome.

Koks S, Pfaff A, Bubb V, Quinn J Int J Mol Sci. 2021; 22(12).

PMID: 34204806 PMC: 8231655. DOI: 10.3390/ijms22126319.

Human Endogenous Retroviruses in Glioblastoma Multiforme.

Yuan Z, Yang Y, Zhang N, Soto C, Jiang X, An Z Microorganisms. 2021; 9(4).

PMID: 33917421 PMC: 8067472. DOI: 10.3390/microorganisms9040764.

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