Expression Patterns of Host Inflammatory Cytokine Genes During Infestation with , a Zoonotic Vector, in Blood Sucking Periods

Overview

Journal Korean J Parasitol

Specialty Parasitology

Date 2018 Mar 14

PMID 29529851

Citations 2

Authors

Mohammad Saiful Islam

Myung-Jo You

Affiliations

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Abstract

Tick saliva is critically important for continuous attachment to the host, blood feeding for days, and transmission of tick-borne pathogens. To characterize the patterns of inflammatory cytokine gene expression during its attachment and blood sucking time, peripheral blood samples of rabbits infested with ticks were collected at different intervals. Blood histamine concentration was evaluated as well as gene encoding IFN-γ, TNF-α, IL-2, IL-6, IL-4, and IL-10 were compared with non-infested rabbits. Blood histamine concentration of tick-infested rabbits during fast feeding time was significantly higher than that of non-infested rabbits. In both nymph and adult tick infested rabbits, expression of TNF-α and IFN-γ genes were decreased significantly (<0.05), while expression of IL-4, IL-6, and IL-10 were increased 1.3 to 7 folds in adult infested rabbits with the exception of IL-6 that was significantly (<0.05) decreased in nymph infested rabbits. IL-2 was not expressed in either nymph or adult infestation. saliva is capable of modulate host responses through a complex correlation with histamine and Th1, Th2 mediated cytokines that suppress the inflammatory responses directed toward inflammatory mediators introduced into the host during tick feeding.

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