The Effects of Fluoxetine on Attachment and Righting Behaviours in Marine (Gibbula Unbilicalis) and Freshwater (Lymnea Stagnalis) Gastropods

Overview

Journal Ecotoxicology

Specialties Environmental Health
Toxicology

Date 2018 Mar 11

PMID 29524054

Citations 3

Authors

Alex T Ford

Bernice Hyett

Daniel Cassidy

Graham Malyon

Affiliations

Soon will be listed here.

Abstract

Recent studies have highlighted that antidepressants such as the selective serotonin reuptake inhibitors (SSRIs) entering aquatic systems through wastewater discharges might impact organisms at environmentally relevant concentrations. In this study, two snail species (Gibbula unbilicalis and Lymnea stagnalis) representing the marine and freshwater environments were exposed to a large range of fluoxetine concentrations (1 ng L-1 mg L) and two distinct behaviours (foot detachment and righting time) were recorded. Fluoxetine significantly caused foot detachment only at the higher of the concentrations (1 mg L) in both species during the course of this short term 1.5 h and 4 h exposures. In this study, lowest observed effect concentrations (LOECs) for foot detachment fell repeatedly within the range for other gastropod snails exposed to fluoxetine. Fluoxetine effected righting times in a concentration dependant manner but only significantly within G. unbilicalis in the highest concentration. Reviewing existing data on the effects of antidepressants on a range of endpoints in gastropod molluscs reveals wide variability of results. The importance of publishing 'negative' and/or non-dramatic results to aid risk assessment are discussed along with the variability between antidepressants, model species, experimental designs and endpoints.

Citing Articles

Screening of Emerging Pollutants (EPs) in Estuarine Water and Phytoremediation Capacity of under Controlled Conditions.

Turcios A, Hielscher M, Duarte B, Fonseca V, Cacador I, Papenbrock J Int J Environ Res Public Health. 2021; 18(3).

PMID: 33499038 PMC: 7908520. DOI: 10.3390/ijerph18030943.

The allelochemical tannic acid affects the locomotion and feeding behaviour of the pond snail, Lymnaea stagnalis, by inhibiting peripheral pathways.

Vehovszky A, Horvath R, Farkas A, Gyori J, Elekes K Invert Neurosci. 2019; 19(3):10.

PMID: 31435741 PMC: 6704085. DOI: 10.1007/s10158-019-0229-7.

Short-term exposure to tricyclic antidepressants delays righting time in marine and freshwater snails with evidence for low-dose stimulation of righting speed by imipramine.

Fong P, DiPenta K, Jonik S, Ward C Environ Sci Pollut Res Int. 2019; 26(8):7840-7846.

PMID: 30680684 DOI: 10.1007/s11356-019-04269-0.

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