Environmental Risk Factors and Changing Spatial Patterns of Human Seropositivity for Echinococcus Spp. in Xiji County, Ningxia Hui Autonomous Region, China

Overview

Journal Parasit Vectors

Publisher Biomed Central

Specialties Parasitology
Tropical Medicine

Date 2018 Mar 11

PMID 29523176

Citations 12

Authors

Angela M Cadavid Restrepo

Yu Rong Yang

Donald P McManus

Darren J Gray

Tamsin S Barnes

Gail M Williams

Ricardo J Soares Magalhaes

Archie C A Clements

Affiliations

Soon will be listed here.

Abstract

Background: Human echinococcoses are parasitic helminth infections that constitute a serious public health concern in several regions across the world. Cystic (CE) and alveolar echinococcosis (AE) in China represent a high proportion of the total global burden of these infections. This study was conducted to predict the spatial distribution of human seropositivity for Echinococcus species in Xiji County, Ningxia Hui Autonomous Region (NHAR), with the aim of identifying communities where targeted prevention and control efforts are required.

Methods: Bayesian geostatistical models with environmental and demographic covariates were developed to predict spatial variation in the risk of human seropositivity for Echinococcus granulosus (the cause of CE) and E. multilocularis (the cause of AE). Data were collected from three cross-sectional surveys of school children conducted in Xiji County in 2002-2003, 2006-2007 and 2012-2013. Environmental data were derived from high-resolution satellite images and meteorological data.

Results: The overall seroprevalence of E. granulosus and E. multilocularis was 33.4 and 12.2%, respectively, across the three surveys. Seropositivity for E. granulosus was significantly associated with summer and winter precipitation, landscape fragmentation variables and the extent of areas covered by forest, shrubland, water and bareland/artificial surfaces. Seropositivity for E. multilocularis was significantly associated with summer and winter precipitations, landscape fragmentation variables and the extent of shrubland and water bodies. Spatial correlation occurred over greater distances for E. granulosus than for E. multilocularis. The predictive maps showed that the risk of seropositivity for E. granulosus expanded across Xiji during the three surveys, while the risk of seropositivity for E. multilocularis became more confined in communities located in the south.

Conclusions: The identification of high-risk areas for seropositivity for these parasites, and a better understanding of the role of the environment in determining the transmission dynamics of Echinococcus spp. may help to guide and monitor improvements in human echinococcosis control strategies by allowing targeted allocation of resources.

Citing Articles

Serological Comparison of Native Antigen ELISAs with Rapid ICT Test Kits for the Diagnosis of Human Alveolar and Cystic Echinococcosis in China.

Yang S, Zhang W, Zhu N, McManus D, Gray D, Clements A Trop Med Infect Dis. 2024; 9(2).

PMID: 38393133 PMC: 10893119. DOI: 10.3390/tropicalmed9020044.

Infection of sheep by Echinococcus multilocularis in Gansu, China: evidence from mitochondrial and nuclear DNA analysis.

Shumuye N, Li L, Li W, Zhang N, Wu Y, Wu Y Infect Dis Poverty. 2023; 12(1):72.

PMID: 37563679 PMC: 10413491. DOI: 10.1186/s40249-023-01120-0.

Targeted and non-targeted proteomics to characterize the parasite proteins of metacestodes.

Muller J, Preza M, Kaethner M, Rufener R, Braga S, Uldry A Front Cell Infect Microbiol. 2023; 13:1170763.

PMID: 37325510 PMC: 10266102. DOI: 10.3389/fcimb.2023.1170763.

Epidemiological characteristics and risk factors for cystic and alveolar echinococcosis in China: an analysis of a national population-based field survey.

Ma T, Hao M, Xue C, Wang X, Han S, Wang Q Parasit Vectors. 2023; 16(1):181.

PMID: 37270512 PMC: 10239570. DOI: 10.1186/s13071-023-05788-z.

How climate, landscape, and economic changes increase the exposure of Echinococcus Spp.

Di X, Li S, Ma B, Di X, Li Y, An B BMC Public Health. 2022; 22(1):2315.

PMID: 36496362 PMC: 9741777. DOI: 10.1186/s12889-022-14803-4.

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