Attentional Functioning in Individuals with 22q11 Deletion Syndrome: Insight from ERPs

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2018 Mar 10

PMID 29520614

Citations 1

Authors

Daniela Mannarelli

Caterina Pauletti

Tommaso Accinni

Luca Carlone

Marianna Frascarelli

Guido Maria Lattanzi

Antonio Curra

Francesco Fattapposta

Affiliations

Soon will be listed here.

Abstract

The 22q11 deletion syndrome (22q11DS), or DiGeorge syndrome (DG), is one of the most common genetic deletion syndromes. DG also carries a high risk for psychiatric disorders, with learning disabilities frequently being reported. Impairments in specific cognitive domains, such as executive functioning and attention, have also been described. The aim of this study was to investigate attentional functioning in a group of subjects with DG using ERPs, and in particular the P300 and CNV components. We studied ten patients with DG and ten healthy subjects that performed a P300 Novelty task and a CNV motor task. P3b amplitude was significantly lower in patients than in controls, while P3b latency was comparable in patients and controls. The P3a parameters were similar in both groups. All CNV amplitudes were significantly lower in DG patients than in controls. DG patients displayed slower reaction times in the CNV motor task than healthy subjects. These results point to a cognitive dysfunction related above all to executive attentional processing in DG patients. In particular, a specific difficulty emerged in selective attention and in the ability to orient and to sustain the anticipatory attention required for an executive motor response.

Citing Articles

Executive functioning in preschoolers with 22q11.2 deletion syndrome and the impact of congenital heart defects.

Everaert E, Vorstman J, Selten I, Slieker M, Wijnen F, Boerma T J Neurodev Disord. 2023; 15(1):15.

PMID: 37173621 PMC: 10181926. DOI: 10.1186/s11689-023-09484-y.

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