Disease Burden of Fractures Among Patients with Osteoporosis in Japan: Health-related Quality of Life, Work Productivity and Activity Impairment, Healthcare Resource Utilization, and Economic Costs

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2018 Mar 10

PMID 29520508

Citations 21

Authors

Saeko Fujiwara

Xiahong Zhao

Cheryl Teoh

Dena H Jaffe

Yurie Taguchi

Affiliations

Soon will be listed here.

Abstract

Osteoporosis remains undertreated in Japan, and bone fractures are the most frequent complications imposing heavy burden on individuals and the community. This paper investigates the clinical and economic burden of fractures among osteoporosis patients in Japan. The Japan National Health and Wellness Survey 2012-2014 database was used for analysis. Respondents aged ≥ 50 years and indicated a physician diagnosis of osteoporosis (N = 1107) were categorized into three subgroups: no prior fracture (N = 693), single fracture (N = 242), and multiple (≥ 2) fractures (N = 172). Health-related quality of life (HRQoL), work productivity and activity impairment, healthcare resource utilization and associated direct and indirect costs were compared across three fracture subgroups adjusting for respondents' sociodemographic and clinical characteristics using generalized linear regression models. The estimated fracture prevalence among respondents with osteoporosis who were ≥ 50 years was 37.4%, of whom 41.5% had multiple fractures. Relative to osteoporosis respondents with no fracture and with single fracture, those with multiple fractures reported significant higher disability in HRQoL, more healthcare resource utilization, and were associated with higher direct costs. Improved treatment of fractures among osteoporosis patients is necessary and may help reduce the clinical and economic burden in this osteoporosis population.

Citing Articles

Availability of Observational Pain Assessment Tools in Hospitalized Patients with Osteoporotic Vertebral Fractures.

Yoshimi Y, Matsuura T, Miyazato K, Takahashi S, Tanaka N, Morinaga H Medicina (Kaunas). 2024; 60(8).

PMID: 39202498 PMC: 11356710. DOI: 10.3390/medicina60081217.

Drug utilization pattern of romosozumab and other osteoporosis treatments in Japan, 2019-2021.

Soen S, Wang A, Hamaya E, Chien H, Lin T J Bone Miner Metab. 2024; 42(6):653-667.

PMID: 38987505 PMC: 11631996. DOI: 10.1007/s00774-024-01530-6.

Comparative effectiveness of denosumab vs alendronate among postmenopausal women with osteoporosis.

Curtis J, Arora T, Liu Y, Lin T, Spangler L, Brunetti V J Bone Miner Res. 2024; 39(7):826-834.

PMID: 38753892 PMC: 11301726. DOI: 10.1093/jbmr/zjae079.

Age and sex are excellent predictors of bone complications in patients with type 2 diabetes with no history of osteoporotic fracture or treatment for osteoporosis.

Yamamoto Y, Matsuba R, Nagasaka T, Shimizu S, Sakai K, Sone M J Int Med Res. 2024; 52(5):3000605241246743.

PMID: 38698517 PMC: 11304493. DOI: 10.1177/03000605241246743.

Body mass index, height, and osteoporotic fracture risk in community-dwelling Japanese people aged 40-74 years.

Nishikura T, Kitamura K, Watanabe Y, Kabasawa K, Takahashi A, Saito T J Bone Miner Metab. 2023; 42(1):47-59.

PMID: 38158407 DOI: 10.1007/s00774-023-01478-z.

References

Reilly M, Zbrozek A, Dukes E . The validity and reproducibility of a work productivity and activity impairment instrument. Pharmacoeconomics. 1993; 4(5):353-65. DOI: 10.2165/00019053-199304050-00006. View

Cauley J, Thompson D, Ensrud K, Scott J, Black D . Risk of mortality following clinical fractures. Osteoporos Int. 2000; 11(7):556-61. DOI: 10.1007/s001980070075. View

Brazier J, Roberts J, Deverill M . The estimation of a preference-based measure of health from the SF-36. J Health Econ. 2002; 21(2):271-92. DOI: 10.1016/s0167-6296(01)00130-8. View

Gabriel S, Tosteson A, Leibson C, Crowson C, Pond G, Hammond C . Direct medical costs attributable to osteoporotic fractures. Osteoporos Int. 2002; 13(4):323-30. DOI: 10.1007/s001980200033. View

Cummings S, Melton L . Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002; 359(9319):1761-7. DOI: 10.1016/S0140-6736(02)08657-9. View

Martin A, Sornay-Rendu E, Chandler J, Duboeuf F, Girman C, Delmas P . The impact of osteoporosis on quality-of-life: the OFELY cohort. Bone. 2002; 31(1):32-6. DOI: 10.1016/s8756-3282(02)00787-1. View

Johnell O, Kanis J, Oden A, Sernbo I, Redlund-Johnell I, Petterson C . Mortality after osteoporotic fractures. Osteoporos Int. 2003; 15(1):38-42. DOI: 10.1007/s00198-003-1490-4. View

Lofland J, Pizzi L, Frick K . A review of health-related workplace productivity loss instruments. Pharmacoeconomics. 2004; 22(3):165-84. DOI: 10.2165/00019053-200422030-00003. View

Hallberg I, Rosenqvist A, Kartous L, Lofman O, Wahlstrom O, Toss G . Health-related quality of life after osteoporotic fractures. Osteoporos Int. 2004; 15(10):834-41. DOI: 10.1007/s00198-004-1622-5. View

10.

Delmas P, Rizzoli R, Cooper C, Reginster J . Treatment of patients with postmenopausal osteoporosis is worthwhile. The position of the International Osteoporosis Foundation. Osteoporos Int. 2004; 16(1):1-5. DOI: 10.1007/s00198-004-1813-0. View

11.

Lips P, van Schoor N . Quality of life in patients with osteoporosis. Osteoporos Int. 2004; 16(5):447-55. DOI: 10.1007/s00198-004-1762-7. View

12.

Colon-Emeric C, Saag K . Osteoporotic fractures in older adults. Best Pract Res Clin Rheumatol. 2006; 20(4):695-706. PMC: 1839833. DOI: 10.1016/j.berh.2006.04.004. View

13.

Caliri A, De Filippis L, Bagnato G, Bagnato G . Osteoporotic fractures: mortality and quality of life. Panminerva Med. 2007; 49(1):21-7. View

14.

Morisky D, Ang A, Krousel-Wood M, Ward H . Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008; 10(5):348-54. PMC: 2562622. DOI: 10.1111/j.1751-7176.2008.07572.x. View

15.

Lee S, Khang Y, Lim K, Kim B, Koh J, Kim G . Clinical risk factors for osteoporotic fracture: a population-based prospective cohort study in Korea. J Bone Miner Res. 2009; 25(2):369-78. DOI: 10.1359/jbmr.090722. View

16.

Becker D, Kilgore M, Morrisey M . The societal burden of osteoporosis. Curr Rheumatol Rep. 2010; 12(3):186-91. DOI: 10.1007/s11926-010-0097-y. View

17.

Pinheiro M, Dos Reis Neto E, Machado F, Omura F, Yang J, Szejnfeld J . Risk factors for osteoporotic fractures and low bone density in pre and postmenopausal women. Rev Saude Publica. 2010; 44(3):479-85. DOI: 10.1590/s0034-89102010000300011. View

18.

Brown P, McNeill R, Leung W, Radwan E, Willingale J . Current and future economic burden of osteoporosis in New Zealand. Appl Health Econ Health Policy. 2011; 9(2):111-23. DOI: 10.2165/11531500-000000000-00000. View

19.

Hagino H, Sawaguchi T, Endo N, Ito Y, Nakano T, Watanabe Y . The risk of a second hip fracture in patients after their first hip fracture. Calcif Tissue Int. 2011; 90(1):14-21. DOI: 10.1007/s00223-011-9545-6. View

20.

Mithal A, Kaur P . Osteoporosis in Asia: a call to action. Curr Osteoporos Rep. 2012; 10(4):245-7. DOI: 10.1007/s11914-012-0114-3. View