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Current Themes in Myocardial and Coronary Vascular Aging

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Date 2018 Mar 10
PMID 29520392
Citations 1
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Abstract

Advancing age will affect every individual and its impact on cardiac health deserves significant attention. The age-related physiological changes occurring in the coronary vasculature, myocardium, and valves set the stage upon which cardiovascular disease can escalate in the elderly population. The overall focus of this review is to highlight new and noteworthy studies and to incorporate reviews related to cardiac senescence in the context of the current state of the field. Lastly, future directions in the field of cardiac aging and the development of novel therapeutics to treat pathophysiological conditions typically associated with advancing age will be discussed.

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References
1.
Brown D, Perry J, Allen M, Sabbah H, Stauffer B, Shaikh S . Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nat Rev Cardiol. 2016; 14(4):238-250. PMC: 5350035. DOI: 10.1038/nrcardio.2016.203. View

2.
Toba H, Cannon P, Yabluchanskiy A, Padmanabhan Iyer R, DArmiento J, Lindsey M . Transgenic overexpression of macrophage matrix metalloproteinase-9 exacerbates age-related cardiac hypertrophy, vessel rarefaction, inflammation, and fibrosis. Am J Physiol Heart Circ Physiol. 2016; 312(3):H375-H383. PMC: 5402013. DOI: 10.1152/ajpheart.00633.2016. View

3.
LeBlanc A, Shipley R, Kang L, Muller-Delp J . Age impairs Flk-1 signaling and NO-mediated vasodilation in coronary arterioles. Am J Physiol Heart Circ Physiol. 2008; 295(6):H2280-8. PMC: 2614537. DOI: 10.1152/ajpheart.00541.2008. View

4.
Ramos G, van den Berg A, Nunes-Silva V, Weirather J, Peters L, Burkard M . Myocardial aging as a T-cell-mediated phenomenon. Proc Natl Acad Sci U S A. 2017; 114(12):E2420-E2429. PMC: 5373357. DOI: 10.1073/pnas.1621047114. View

5.
Lesnefsky E, Chen Q, Hoppel C . Mitochondrial Metabolism in Aging Heart. Circ Res. 2016; 118(10):1593-611. PMC: 5009371. DOI: 10.1161/CIRCRESAHA.116.307505. View