Can Dentists Detect Multiple Myeloma Through Oral Manifestations?

Overview

Journal Hematol Transfus Cell Ther

Specialty Hematology

Date 2018 Mar 10

PMID 29519372

Citations 4

Authors

Thais Miranda Xavier de Almeida

Edila Figueredo Feitosa Cavalcanti

Alessandra da Silva Freitas

Roberto Jose Pessoa de Magalhaes

Angelo Maiolino

Sandra Regina Torres

Affiliations

Soon will be listed here.

Abstract

Objective: To review published data on oral manifestations of multiple myeloma.

Methods: An electronic database search was performed of articles published from 1971 to November 2016 in order to identify studies that reported oral manifestations of patients with multiple myeloma. Case reports and case series with oral manifestations of multiple myeloma in English were included in the study. An additional search was performed of the references of the selected articles.

Results: Thirty-seven articles that reported 81 patients with oral manifestations of multiple myeloma were selected: 30 case reports (82%) and seven case series (18%). The most common clinical features in the dental cavity were swelling (65.4%), bone pain (33.3%), paresthesia (27.1%) and amyloidosis lesions (11.1%). Osteolytic lesions detected on imaging exams were reported in the majority of the patients (90.1%) as plasmacytomas or 'punched-out' lesions.

Conclusions: Swelling and osteolytic lesions represent the most common clinical and radiographic signs of the jaws relating to multiple myeloma, respectively.

Citing Articles

Imaging aspects of maxillomandibular bone alterations in patients with multiple myeloma treated with bisphosphonates: A systematic review.

Gonzaga A, Morais H, Oliveira C, Campos M, Diaz C, Custodio M Imaging Sci Dent. 2024; 54(3):221-231.

PMID: 39371309 PMC: 11450414. DOI: 10.5624/isd.20240032.

Beyond the mouth: Uncovering non-secretory multiple myeloma through oral symptoms.

Isaias P, Costa F, Amorim P, da Silva R, Sousa F, Pereira K Imaging Sci Dent. 2024; 54(2):211-220.

PMID: 38948192 PMC: 11211024. DOI: 10.5624/isd.20230257.

The Bloody Crossroads: Interactions between Periodontitis and Hematologic Diseases.

Lobacz M, Mertowska P, Mertowski S, Kozinska A, Kwasniewski W, Kos M Int J Mol Sci. 2024; 25(11).

PMID: 38892299 PMC: 11173219. DOI: 10.3390/ijms25116115.

Osteolytic Lesion of the Maxilla in an Undiagnosed Multiple Myeloma Patient Identified Incidentally by Cone Beam Computed Tomography.

Ali S, Khalifa H, Bayoumi A, Almazrooa S, Bin Madi N, Akeel S Am J Case Rep. 2022; 23:e936585.

PMID: 35972908 PMC: 9393049. DOI: 10.12659/AJCR.936585.

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