Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats

Overview

Journal Nutrients

Date 2018 Mar 10

PMID 29518911

Citations 14

Authors

Iris Gines

Katherine Gil-Cardoso

Joan Serrano

Angela Casanova-Marti

MTeresa Blay

Montserrat Pinent

Anna Ardevol

Ximena Terra

Affiliations

Soon will be listed here.

Abstract

Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome. Grape-seed proanthocyanins (GSPE) have showed very positive effects against all these metabolic disruptions; however, there is, as yet, no consensus about their effectiveness against an obesogenic challenge, such as a cafeteria diet. We determined the effectiveness of a dose of 500 mg GSPE/kg b.w. (body weight) against the obesogenic effects of a 17-week cafeteria diet, administered as a sub-chronic treatment, 10-15 days before, intermittently and at the end of the diet, in Wistar rats. Body weight, adiposity, indirect calorimetry and plasma parameters were analyzed. GSPE pre-treatment showed a long-lasting effect on body weight and adiposity that was maintained for seven weeks after the last dose. A corrective treatment was administered for the last two weeks of the cafeteria diet intervention; however, it did not effectively correct any of the parameters assessed. The most effective treatment was an intermittent GSPE dosage, administered every second week during the cafeteria diet. This limited body weight gain, adiposity and most lipotoxic effects. Our results support the administration of this GSPE dose, keeping an intermittent interval between dosages longer than every second week, to improve obesogenic disruptions produced by a cafeteria diet.

Citing Articles

Grape-Seed Proanthocyanidin Extract (GSPE) Modulates Diurnal Rhythms of Hepatic Metabolic Genes and Metabolites, and Reduces Lipid Deposition in Cafeteria-Fed Rats in a Time-of-Day-Dependent Manner.

Rodriguez R, de Assis L, Calvo E, Colom-Pellicer M, Quesada-Vazquez S, Cruz-Carrion A Mol Nutr Food Res. 2024; 68(23):e2400554.

PMID: 39523911 PMC: 11653167. DOI: 10.1002/mnfr.202400554.

Effects of grape seed proanthocyanidin extract on cholesterol metabolism and antioxidant status in finishing pigs.

Wang W, Xu M, Diao H, Long Q, Gan F, Mao Y Sci Rep. 2024; 14(1):21117.

PMID: 39256553 PMC: 11387843. DOI: 10.1038/s41598-024-72075-x.

GSPE Pre-Treatment Exerts Long-Lasting Preventive Effects against Aging-Induced Changes in the Colonic Enterohormone Profile of Female Rats.

Miguens-Gomez A, Sierra-Cruz M, Blay M, Rodriguez-Gallego E, Beltran-Debon R, Terra X Int J Mol Sci. 2023; 24(9).

PMID: 37175514 PMC: 10177949. DOI: 10.3390/ijms24097807.

Intestinal Morphometric Changes Induced by a Western-Style Diet in Wistar Rats and GSPE Counter-Regulatory Effect.

Segu H, Jalsevac F, Pinent M, Ardevol A, Terra X, Blay M Nutrients. 2022; 14(13).

PMID: 35807788 PMC: 9268310. DOI: 10.3390/nu14132608.

Grape-Seed Proanthocyanidin Extract Reverts Obesity-Related Metabolic Derangements in Aged Female Rats.

Sierra-Cruz M, Miguens-Gomez A, Grau-Bove C, Rodriguez-Gallego E, Blay M, Pinent M Nutrients. 2021; 13(6).

PMID: 34208508 PMC: 8234113. DOI: 10.3390/nu13062059.

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