Wake-up Stroke is Not Associated with Sleep-disordered Breathing in Women

Overview

Journal Neurol Clin Pract

Date 2018 Mar 9

PMID 29517077

Citations 5

Authors

Devin L Brown

Chengwei Li

Ronald D Chervin

Erin Case

Nelda M Garcia

Susan D Tower

Lynda D Lisabeth

Affiliations

Soon will be listed here.

Abstract

Background: We sought to investigate the frequency of wake-up stroke (WUS) and its association with sleep-disordered breathing (SDB) in women.

Methods: Within a population-based study, women with acute ischemic stroke were asked about their stroke symptom onset time. SDB screening was performed with the well-validated ApneaLink Plus device; SDB was defined by a respiratory event index ≥10. Logistic regression was used to test the association between SDB presence and severity and WUS unadjusted and adjusted for potential confounders including prestroke depression and sleep duration.

Results: Among 466 participants, the median age was 67.0 years (interquartile range [IQR] 58.0, 77.0), 55% were Mexican American, and the median initial NIH Stroke Scale score was 3.0 (IQR 1.0, 6.0). Stroke symptom onset occurred during nocturnal sleep (25.3%), during a nap (3.9%), during wakefulness (65.9%), or unknown (4.9%). In those with SDB screening performed (n = 259), a median of 11 days (IQR 5, 17) poststroke, WUS was not associated with the presence or severity (respiratory event index) of SDB in unadjusted or adjusted analysis.

Conclusions: In this population-based study, WUS represented about 30% of all generally mild severity ischemic strokes in women and was not associated with SDB.

Citing Articles

Meta-Analysis of the Association Between Atrial Fibrillation, Hypertension, Sleep-Disordered Breathing, and Wake-Up Stroke.

Zhou J, Xu J, Cheng A, Kadier Y, Liang X, Mutailipu M Tex Heart Inst J. 2023; 50(3).

PMID: 37199028 PMC: 10353276. DOI: 10.14503/THIJ-21-7698.

No Difference in Sleep Desaturations Severity between Patients with Wake-Up and Non-Wake-Up Stroke: A PRESS Study Results.

Klobucnikova K, Kollar B, Jurik M, Valovicova K, Hardonova M, Poddany M Life (Basel). 2023; 13(2).

PMID: 36836872 PMC: 9959436. DOI: 10.3390/life13020517.

Wake-up strokes are linked to obstructive sleep apnea and worse early functional outcome.

Haula T, Puustinen J, Takala M, Holm A Brain Behav. 2021; 11(8):e2284.

PMID: 34291603 PMC: 8413798. DOI: 10.1002/brb3.2284.

Wake-up stroke is not associated with obstructive sleep apnea.

Schutz S, Lisabeth L, Gibbs R, Shi X, Case E, Chervin R Sleep Med. 2021; 81:158-162.

PMID: 33684605 PMC: 8563108. DOI: 10.1016/j.sleep.2021.02.010.

Wake-up stroke: imaging-based diagnosis and recanalization therapy.

Zhang Y, Zhang J, Wang X, Wang Y, Anderson C, Wu Y J Neurol. 2020; 268(11):4002-4012.

PMID: 32671526 DOI: 10.1007/s00415-020-10055-7.

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