Association of TNF-α-308(G/A) and -238(G/A) Polymorphisms with Non-traumatic Osteonecrosis of the Femoral Head Risks: a Meta-analysis

Overview

Journal Int Orthop

Specialty Orthopedics

Date 2018 Mar 9

PMID 29516236

Citations 9

Authors

Yizhong Peng

Yuenan Liu

Donghua Huang

Wei Huang

Zengwu Shao

Affiliations

Soon will be listed here.

Abstract

Purpose: The association between TNF-α-308(G/A) and -238(G/A) polymorphisms and the susceptibility of non-traumatic osteonecrosis of the femoral head (NONFH) was investigated in many studies with conflicting results. We aimed to conduct a meta-analysis to evaluate the relationship between them comprehensively.

Methods: Relevant literatures published in PubMed, Web of Science, Embase, Cochrane library databases, China National Knowledge Infrastructure (CNKI), WANFANG Data, and China Science and Technology Journal Database (CSTJ) updated to January 30, 2018, were reviewed by two investigators independently. Odds ratios (ORs) and its 95% confidence intervals (95% CIs) were calculated by a fixed-effect model based on the indistinctive heterogeneity.

Results: For TNF-α-308(G/A) polymorphism, we recruited five studies including 432 NONFH patients and 760 controls and a statistically significant association was identified in Asians in four modes consisting of alleles mode (OR = 0.648, 95% CI 0.475-0.885), homozygote mode (OR = 0.330, 95% CI 0.136-0.802), dominant mode (OR = 0.344, 95% CI 0.143-0.827), and recessive mode (OR = 0.674, 95% CI 0.468-0.971), but no significant association was observed in Caucasians. For TNF-α-238(G/A) polymorphism, three eligible studies including 275 cases and 610 controls were evaluated and there was a significant association in alleles mode (OR = 0.270, 95% CI 0.4148-0.490) as well as recessive mode (OR = 0.254, 95% CI 0.138-0.468).

Conclusion: This meta-analysis shows that TNF-α-308(G/A) and -238(G/A) polymorphisms are associated with the susceptibility of NONFH, while the significant association for 308(G/A) is mainly observed in Asians.

Citing Articles

Integrative analyses of genes related to femoral head osteonecrosis: an umbrella review of systematic reviews and meta-analyses of observational studies.

Lee S, Yoo J, Kang Y J Orthop Surg Res. 2022; 17(1):182.

PMID: 35346283 PMC: 8961967. DOI: 10.1186/s13018-022-03079-4.

An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development.

Wang R, Li R, Liu R BMC Med Genomics. 2022; 15(1):5.

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[Predictive effect of femoral neck strength composite indexes on femoral head collapse in non-traumatic osteonecrosis of femoral head].

Lin T, Yang P, Cai K, Li Z, Pang F, Zhang Q Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021; 35(8):967-972.

PMID: 34387423 PMC: 8403992. DOI: 10.7507/1002-1892.202103168.

Nontraumatic Osteonecrosis of the Femoral Head: Where Do We Stand Today?: A 5-Year Update.

Mont M, Salem H, Piuzzi N, Goodman S, Jones L J Bone Joint Surg Am. 2020; 102(12):1084-1099.

PMID: 32282421 PMC: 7508290. DOI: 10.2106/JBJS.19.01271.

Osteonecrosis of the femoral head: genetic basis.

Wang T, Azeddine B, Mah W, Harvey E, Rosenblatt D, Seguin C Int Orthop. 2018; 43(3):519-530.

PMID: 30328481 DOI: 10.1007/s00264-018-4172-8.

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