» Articles » PMID: 29514995

Characteristics of and Risk Factors for Death in Elderly Patients with Acute Kidney Injury: a Multicentre Retrospective Study in China

Overview
Journal Postgrad Med J
Specialty General Medicine
Date 2018 Mar 9
PMID 29514995
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

Purpose Of The Study: The incidence of acute kidney injury (AKI) with a poor prognosis in the elderly has been increasing each year. This study aimed to investigate the clinical characteristics of and risk factors for death from AKI in the elderly and help improve prognosis.

Study Design: This study was a retrospective cohort study based on data from adult patients (≥18 years old) admitted to 15 hospitals in China between 1 January 2009 and 31 December 2011. The characteristics of AKI in the elderly were compared with those in younger patients.

Results: In elderly patients with AKI, rates of hypertension, cardiovascular disease and multiple organ dysfunction syndrome (MODS) were higher than in younger patients (44.2% vs 31.2%, 16.1% vs 4.6% and 20.9% vs 16.9%, respectively), the length of ICU stay was longer (3.8 days vs 2.7 days, P=0.019) and renal biopsy (1.0% vs 7.13%, P<0.001) and dialysis (9.6% vs 19.2%, P<0.001) were performed less. Hospital-acquired (HA) AKI was more common than community-acquired (CA) AKI (60.3% vs 39.7%), while the most common cause of AKI was pre-renal (53.5%). Multiple logistic regression analysis showed that age (OR 1.041, 95% CI 1.023 to 1.059), cardiovascular disease (OR 1.980, 95% CI 1.402 to 2.797), cancer (OR 2.302, 95% CI 1.654 to 3.203), MODS (OR 3.023, 95% CI 1.627 to 5.620) and mechanical ventilation (OR 2.408, 95% CI 1.187 to 4.887) were significant risk factors for death.

Conclusions: HA-AKI and pre-renal AKI were more common in the elderly. Age, cardiovascular disease, cancer, MODS and mechanical ventilation were independent risk factors for death in the elderly with AKI.

Citing Articles

Acute Kidney Injury Prognosis Prediction Using Machine Learning Methods: A Systematic Review.

Lin Y, Shi T, Kong G Kidney Med. 2025; 7(1):100936.

PMID: 39758155 PMC: 11699606. DOI: 10.1016/j.xkme.2024.100936.


Feasibility of Short-Term Use of Ivabradine in Critical Ill Patients Who Have Atrial Fibrillation and Tachycardia.

Lin W, Peng P, Lin S Acta Cardiol Sin. 2024; 40(4):373-382.

PMID: 39045379 PMC: 11261355. DOI: 10.6515/ACS.202407_40(4).20240411A.


Kidney biopsy in very elderly patients: indications, therapeutic impact and complications.

Fedi M, Bobot M, Torrents J, Gobert P, Magnant E, Knefati Y BMC Nephrol. 2021; 22(1):362.

PMID: 34727880 PMC: 8561868. DOI: 10.1186/s12882-021-02559-9.


Development of mortality prediction model in the elderly hospitalized AKI patients.

Peng J, Wu T, Wu X, Yan P, Kang Y, Liu Y Sci Rep. 2021; 11(1):15157.

PMID: 34312443 PMC: 8313696. DOI: 10.1038/s41598-021-94271-9.


Acute kidney injury is an independent predictor of in-hospital mortality in a general medical ward: A retrospective study from a tertiary care centre in south India.

Chandiraseharan V, Kalimuthu M, Prakash T, George T, Rajenesh A, Jayaseelan V Indian J Med Res. 2020; 152(4):386-392.

PMID: 33380703 PMC: 8061603. DOI: 10.4103/ijmr.IJMR_1685_18.


References
1.
Zeng X, McMahon G, Brunelli S, Bates D, Waikar S . Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals. Clin J Am Soc Nephrol. 2013; 9(1):12-20. PMC: 3878695. DOI: 10.2215/CJN.02730313. View

2.
Yang L, Xing G, Wang L, Wu Y, Li S, Xu G . Acute kidney injury in China: a cross-sectional survey. Lancet. 2015; 386(10002):1465-71. DOI: 10.1016/S0140-6736(15)00344-X. View

3.
Doi K, Rabb H . Impact of acute kidney injury on distant organ function: recent findings and potential therapeutic targets. Kidney Int. 2016; 89(3):555-64. DOI: 10.1016/j.kint.2015.11.019. View

4.
Yilmaz R, Erdem Y . Acute kidney injury in the elderly population. Int Urol Nephrol. 2009; 42(1):259-71. DOI: 10.1007/s11255-009-9629-7. View

5.
Ali T, Khan I, Simpson W, Prescott G, Townend J, Smith W . Incidence and outcomes in acute kidney injury: a comprehensive population-based study. J Am Soc Nephrol. 2007; 18(4):1292-8. DOI: 10.1681/ASN.2006070756. View