Genetics and Crime: Integrating New Genomic Discoveries Into Psychological Research About Antisocial Behavior

Overview

Journal Psychol Sci

Specialty Psychology

Date 2018 Mar 8

PMID 29513605

Citations 25

Authors

J Wertz

A Caspi

D W Belsky

A L Beckley

L Arseneault

J C Barnes

D L Corcoran

S Hogan

R M Houts

N Morgan

C L Odgers

J A Prinz

K Sugden

B S Williams

R Poulton

T E Moffitt

Affiliations

Soon will be listed here.

Abstract

Drawing on psychological and sociological theories of crime causation, we tested the hypothesis that genetic risk for low educational attainment (assessed via a genome-wide polygenic score) is associated with criminal offending. We further tested hypotheses of how polygenic risk relates to the development of antisocial behavior from childhood through adulthood. Across the Dunedin and Environmental Risk (E-Risk) birth cohorts of individuals growing up 20 years and 20,000 kilometers apart, education polygenic scores predicted risk of a criminal record with modest effects. Polygenic risk manifested during primary schooling in lower cognitive abilities, lower self-control, academic difficulties, and truancy, and it was associated with a life-course-persistent pattern of antisocial behavior that onsets in childhood and persists into adulthood. Crime is central in the nature-nurture debate, and findings reported here demonstrate how molecular-genetic discoveries can be incorporated into established theories of antisocial behavior. They also suggest that improving school experiences might prevent genetic influences on crime from unfolding.

Citing Articles

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References

Trouton A, Spinath F, Plomin R . Twins early development study (TEDS): a multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Res. 2003; 5(5):444-8. DOI: 10.1375/136905202320906255. View

Moffitt T, Arseneault L, Belsky D, Dickson N, Hancox R, Harrington H . A gradient of childhood self-control predicts health, wealth, and public safety. Proc Natl Acad Sci U S A. 2011; 108(7):2693-8. PMC: 3041102. DOI: 10.1073/pnas.1010076108. View

McCarty C, Chisholm R, Chute C, Kullo I, Jarvik G, Larson E . The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics. 2011; 4:13. PMC: 3038887. DOI: 10.1186/1755-8794-4-13. View

Abecasis G, Auton A, Brooks L, DePristo M, Durbin R, Handsaker R . An integrated map of genetic variation from 1,092 human genomes. Nature. 2012; 491(7422):56-65. PMC: 3498066. DOI: 10.1038/nature11632. View

Catalano R, Haggerty K, Oesterle S, Fleming C, Hawkins J . The importance of bonding to school for healthy development: findings from the Social Development Research Group. J Sch Health. 2004; 74(7):252-61. DOI: 10.1111/j.1746-1561.2004.tb08281.x. View

Odgers C, Caspi A, Broadbent J, Dickson N, Hancox R, Harrington H . Prediction of differential adult health burden by conduct problem subtypes in males. Arch Gen Psychiatry. 2007; 64(4):476-84. DOI: 10.1001/archpsyc.64.4.476. View

Euesden J, Lewis C, OReilly P . PRSice: Polygenic Risk Score software. Bioinformatics. 2015; 31(9):1466-8. PMC: 4410663. DOI: 10.1093/bioinformatics/btu848. View

Dudbridge F . Power and predictive accuracy of polygenic risk scores. PLoS Genet. 2013; 9(3):e1003348. PMC: 3605113. DOI: 10.1371/journal.pgen.1003348. View

Rosenberg N, Huang L, Jewett E, Szpiech Z, Jankovic I, Boehnke M . Genome-wide association studies in diverse populations. Nat Rev Genet. 2010; 11(5):356-66. PMC: 3079573. DOI: 10.1038/nrg2760. View

10.

Sherry S, Ward M, Kholodov M, Baker J, Phan L, Smigielski E . dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 2000; 29(1):308-11. PMC: 29783. DOI: 10.1093/nar/29.1.308. View

11.

Moffitt T . Teen-aged mothers in contemporary Britain. J Child Psychol Psychiatry. 2002; 43(6):727-42. DOI: 10.1111/1469-7610.00082. View

12.

Poulton R, Moffitt T, Silva P . The Dunedin Multidisciplinary Health and Development Study: overview of the first 40 years, with an eye to the future. Soc Psychiatry Psychiatr Epidemiol. 2015; 50(5):679-93. PMC: 4412685. DOI: 10.1007/s00127-015-1048-8. View

13.

Moffitt T . Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev. 1993; 100(4):674-701. View

14.

Caspi A, Taylor A, Smart M, Jackson J, Tagami S, Moffitt T . Can women provide reliable information about their children's fathers? cross-informant agreement about men's lifetime antisocial behaviour. J Child Psychol Psychiatry. 2001; 42(7):915-20. DOI: 10.1111/1469-7610.00787. View

15.

Visscher P, Wray N, Zhang Q, Sklar P, McCarthy M, Brown M . 10 Years of GWAS Discovery: Biology, Function, and Translation. Am J Hum Genet. 2017; 101(1):5-22. PMC: 5501872. DOI: 10.1016/j.ajhg.2017.06.005. View

16.

Chang C, Chow C, Tellier L, Vattikuti S, Purcell S, Lee J . Second-generation PLINK: rising to the challenge of larger and richer datasets. Gigascience. 2015; 4:7. PMC: 4342193. DOI: 10.1186/s13742-015-0047-8. View

17.

Rietveld C, Esko T, Davies G, Pers T, Turley P, Benyamin B . Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proc Natl Acad Sci U S A. 2014; 111(38):13790-4. PMC: 4183313. DOI: 10.1073/pnas.1404623111. View

18.

Milne B, Moffitt T, Crump R, Poulton R, Rutter M, Sears M . How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study. Psychol Med. 2008; 38(12):1793-802. PMC: 3752774. DOI: 10.1017/S0033291708003115. View

19.

Heckman J . Skill formation and the economics of investing in disadvantaged children. Science. 2006; 312(5782):1900-2. DOI: 10.1126/science.1128898. View

20.

Trzesniewski K, Moffitt T, Caspi A, Taylor A, Maughan B . Revisiting the association between reading achievement and antisocial behavior: new evidence of an environmental explanation from a twin study. Child Dev. 2006; 77(1):72-88. DOI: 10.1111/j.1467-8624.2006.00857.x. View