Nanowire Arrays Restore Vision in Blind Mice

Overview

Journal Nat Commun

Specialty Biology

Date 2018 Mar 8

PMID 29511183

Citations 44

Authors

Jing Tang

Nan Qin

Yan Chong

Yupu Diao

Yiliguma

Zhexuan Wang

Tian Xue

Min Jiang

Jiayi Zhang

Gengfeng Zheng

Affiliations

Soon will be listed here.

Abstract

The restoration of light response with complex spatiotemporal features in retinal degenerative diseases towards retinal prosthesis has proven to be a considerable challenge over the past decades. Herein, inspired by the structure and function of photoreceptors in retinas, we develop artificial photoreceptors based on gold nanoparticle-decorated titania nanowire arrays, for restoration of visual responses in the blind mice with degenerated photoreceptors. Green, blue and near UV light responses in the retinal ganglion cells (RGCs) are restored with a spatial resolution better than 100 µm. ON responses in RGCs are blocked by glutamatergic antagonists, suggesting functional preservation of the remaining retinal circuits. Moreover, neurons in the primary visual cortex respond to light after subretinal implant of nanowire arrays. Improvement in pupillary light reflex suggests the behavioral recovery of light sensitivity. Our study will shed light on the development of a new generation of optoelectronic toolkits for subretinal prosthetic devices.

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