Type I Interferon Receptor Knockout Mice As Models for Infection of Highly Pathogenic Viruses with Outbreak Potential

Overview

Journal Zool Res

Publisher Science Press

Specialties Biology
Veterinary Medicine

Date 2018 Mar 8

PMID 29511140

Citations 22

Authors

Gary Wong

Xiang-Guo Qiu

Affiliations

Soon will be listed here.

Abstract

Due to their inability to generate a complete immune response, mice knockout for type I interferon (IFN) receptors () are more susceptible to viral infections, and are thus commonly used for pathogenesis studies. This mouse model has been used to study many diseases caused by highly pathogenic viruses from many families, including the , , , , , and . In this review, we summarize the findings from these animal studies, and discuss the pros and cons of using this model versus other known methods for studying pathogenesis in animals.

Citing Articles

Establishment and application of a wild neonatal mouse model infected with an Echovirus 30 isolate.

Qu Y, Wang J, Chen Y, Xiao S, He Y, Zhang N Virol J. 2025; 22(1):69.

PMID: 40075457 PMC: 11899154. DOI: 10.1186/s12985-025-02684-z.

RT-RPA as a dual tool for detection and phylogenetic analysis of epidemic arthritogenic alphaviruses.

Sridhar S, Tonto P, Lumkong L, Martins Netto E, Brites C, Wang W Sci Rep. 2024; 14(1):30134.

PMID: 39627454 PMC: 11615341. DOI: 10.1038/s41598-024-81763-7.

Lack of Lloviu Virus Disease Development in Ferret Model.

Fletcher P, ODonnell K, Rhoderick J, Henderson C, Okumura A, Bushmaker T Emerg Infect Dis. 2024; 30(12):2639-2642.

PMID: 39592411 PMC: 11616650. DOI: 10.3201/eid3012.240818.

Increased Virulence of Midge Cell-Derived Bluetongue Virus in IFNAR Mice.

Drolet B, Reister-Hendricks L, Mayo C, Rodgers C, Molik D, McVey D Viruses. 2024; 16(9).

PMID: 39339950 PMC: 11437402. DOI: 10.3390/v16091474.

The Rift Valley fever (RVF) vaccine candidate 40Fp8 shows an extreme attenuation in IFNARKO mice following intranasal inoculation.

Borrego B, Alonso C, Moreno S, de la Losa N, Sanchez-Cordon P, Brun A PLoS Negl Trop Dis. 2024; 18(8):e0012011.

PMID: 39159263 PMC: 11361746. DOI: 10.1371/journal.pntd.0012011.

References

Weaver S, Ferro C, Barrera R, Boshell J, Navarro J . Venezuelan equine encephalitis. Annu Rev Entomol. 2003; 49:141-74. DOI: 10.1146/annurev.ento.49.061802.123422. View

DOrtenzio E, Matheron S, Yazdanpanah Y, de Lamballerie X, Hubert B, Piorkowski G . Evidence of Sexual Transmission of Zika Virus. N Engl J Med. 2016; 374(22):2195-8. DOI: 10.1056/NEJMc1604449. View

Haensch S, Bianucci R, Signoli M, Rajerison M, Schultz M, Kacki S . Distinct clones of Yersinia pestis caused the black death. PLoS Pathog. 2010; 6(10):e1001134. PMC: 2951374. DOI: 10.1371/journal.ppat.1001134. View

Theves C, Crubezy E, Biagini P . History of Smallpox and Its Spread in Human Populations. Microbiol Spectr. 2016; 4(4). DOI: 10.1128/microbiolspec.PoH-0004-2014. View

LEON C . Sequelae of Venezuelan equine encephalitis in humans: a four year follow-up. Int J Epidemiol. 1975; 4(2):131-40. DOI: 10.1093/ije/4.2.131. View

DICK G, KITCHEN S, HADDOW A . Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952; 46(5):509-20. DOI: 10.1016/0035-9203(52)90042-4. View

Johnson N, Mueller J . Updating the accounts: global mortality of the 1918-1920 "Spanish" influenza pandemic. Bull Hist Med. 2002; 76(1):105-15. DOI: 10.1353/bhm.2002.0022. View

Rieger T, Merkler D, Gunther S . Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers. PLoS One. 2013; 8(8):e72290. PMC: 3750052. DOI: 10.1371/journal.pone.0072290. View

Meier K, Gardner C, Khoretonenko M, Klimstra W, Ryman K . A mouse model for studying viscerotropic disease caused by yellow fever virus infection. PLoS Pathog. 2009; 5(10):e1000614. PMC: 2749449. DOI: 10.1371/journal.ppat.1000614. View

10.

Rossi S, Tesh R, Azar S, Muruato A, Hanley K, Auguste A . Characterization of a Novel Murine Model to Study Zika Virus. Am J Trop Med Hyg. 2016; 94(6):1362-1369. PMC: 4889758. DOI: 10.4269/ajtmh.16-0111. View

11.

Cao-Lormeau V, Roche C, Teissier A, Robin E, Berry A, Mallet H . Zika virus, French polynesia, South pacific, 2013. Emerg Infect Dis. 2014; 20(6):1085-6. PMC: 4036769. DOI: 10.3201/eid2006.140138. View

12.

Hubalek Z, Halouzka J . West Nile fever--a reemerging mosquito-borne viral disease in Europe. Emerg Infect Dis. 1999; 5(5):643-50. PMC: 2627720. DOI: 10.3201/eid0505.990505. View

13.

Bausch D, Nichol S, Muyembe-Tamfum J, Borchert M, Rollin P, Sleurs H . Marburg hemorrhagic fever associated with multiple genetic lineages of virus. N Engl J Med. 2006; 355(9):909-19. DOI: 10.1056/NEJMoa051465. View

14.

Warfield K, Bradfute S, Wells J, Lofts L, Cooper M, Alves D . Development and characterization of a mouse model for Marburg hemorrhagic fever. J Virol. 2009; 83(13):6404-15. PMC: 2698517. DOI: 10.1128/JVI.00126-09. View

15.

Coleman K . Caring for nonhuman primates in biomedical research facilities: scientific, moral and emotional considerations. Am J Primatol. 2010; 73(3):220-5. PMC: 2974947. DOI: 10.1002/ajp.20855. View

16.

Murray K, Ruktanonchai D, Hesalroad D, Fonken E, Nolan M . West Nile virus, Texas, USA, 2012. Emerg Infect Dis. 2013; 19(11):1836-8. PMC: 3837649. DOI: 10.3201/eid1911.130768. View

17.

Deckard D, Chung W, Brooks J, Smith J, Woldai S, Hennessey M . Male-to-Male Sexual Transmission of Zika Virus--Texas, January 2016. MMWR Morb Mortal Wkly Rep. 2016; 65(14):372-4. DOI: 10.15585/mmwr.mm6514a3. View

18.

Belser J, Wadford D, Pappas C, Gustin K, Maines T, Pearce M . Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice. J Virol. 2010; 84(9):4194-203. PMC: 2863721. DOI: 10.1128/JVI.02742-09. View

19.

Yun N, Poussard A, Seregin A, Walker A, Smith J, Aronson J . Functional interferon system is required for clearance of lassa virus. J Virol. 2012; 86(6):3389-92. PMC: 3302329. DOI: 10.1128/JVI.06284-11. View

20.

Smith D, Steele K, Shamblin J, Honko A, Johnson J, Reed C . The pathogenesis of Rift Valley fever virus in the mouse model. Virology. 2010; 407(2):256-67. DOI: 10.1016/j.virol.2010.08.016. View