Graves' Hyperthyroidism in Pregnancy: a Clinical Review

Overview

Journal Clin Diabetes Endocrinol

Publisher Biomed Central

Specialty Endocrinology

Date 2018 Mar 7

PMID 29507751

Citations 21

Authors

Caroline T Nguyen

Elizabeth B Sasso

Lorayne Barton

Jorge H Mestman

Affiliations

Soon will be listed here.

Abstract

Background: Graves' hyperthyroidism affects 0.2% of pregnant women. Establishing the correct diagnosis and effectively managing Graves' hyperthyroidism in pregnancy remains a challenge for physicians.

Main: The goal of this paper is to review the diagnosis and management of Graves' hyperthyroidism in pregnancy. The paper will discuss preconception counseling, etiologies of hyperthyroidism, thyroid function testing, pregnancy-related complications, maternal management, including thyroid storm, anti-thyroid drugs and the complications for mother and fetus, fetal and neonatal thyroid function, neonatal management, and maternal post-partum management.

Conclusion: Establishing the diagnosis of Graves' hyperthyroidism early, maintaining euthyroidism, and achieving a serum total T4 in the upper limit of normal throughout pregnancy is key to reducing the risk of maternal, fetal, and newborn complications. The key to a successful pregnancy begins with preconception counseling.

Citing Articles

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An Unusual and Severe Thyrotoxicosis in a Twin Pregnancy: Fortune Favors the Brave.

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Best practices in the laboratory diagnosis, prognostication, prediction, and monitoring of Graves' disease: role of TRAbs.

Kalra S, Selim S, Shrestha D, Somasundaram N, Raza S, Baruah M BMC Endocr Disord. 2024; 24(1):274.

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Association of vitamin A with gestational diabetes and thyroid disorders in pregnancy and their influence on maternal, fetal, and neonatal outcomes.

Qadeer A, Ishaq M, Safi A, Akbar A, Asif S, Komel A Ther Adv Reprod Health. 2024; 18:26334941241271542.

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Neonatal Thyrotoxicosis in Infants of Mothers with Graves' Disease Treated for Radioiodine-Induced Hypothyroidism: A Literature Review.

Jankovski L, Grosek S, Zerjav M, Vidmar Simic M, Zaletel K Children (Basel). 2024; 11(8).

PMID: 39201903 PMC: 11352502. DOI: 10.3390/children11080968.

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