Polymorphisms and HIV-1 Mother-to-child Transmission in Zambian Population

Overview

Journal J Matern Fetal Neonatal Med

Publisher Informa Healthcare

Specialty Gynecology & Obstetrics

Date 2018 Mar 7

PMID 29506422

Citations 3

Authors

Luisa Zupin

Vania Polesello

Ludovica Segat

Anselmo Jiro Kamada

Louise Kuhn

Sergio Crovella

Affiliations

Soon will be listed here.

Abstract

Human Beta Defensin-1 (hBD-1) is a component of the innate immune system, the first line of defence against pathogens, already reported as involved in the susceptibility to HIV-1 infection and HIV-1 mother-to-child transmission (MTCT) in different populations. We investigated the role of gene (encoding for hBD-1) functional polymorphisms in the susceptibility to HIV-1 MTCT in a population from Zambia. Four selected polymorphisms within gene, three at the 5' untranslated region (UTR), namely -52G > A (rs1799946), -44C > G (rs1800972) and -20G > A (rs11362) and one in the 3'UTR, c.*87A > G (rs1800972), were genotyped in 101 HIV-1 positive mothers (26 transmitters -27% and 75 not transmitters -73%) and 331 infants born to HIV-1 infected mothers (85 HIV-1 positive -26% and 246 exposed but not infected -74%). c.*87-A allele was more frequent among HIV- children with respect to HIV+ (with intrauterine MTCT). Concerning haplotypes, GCGA haplotype resulted more represented in HIV- than HIV+ infants and ACGG haplotype presented increased frequency in HIV- children respect to HIV+ (with intra-partum MTCT) ( = .02, = .002 and = .006, respectively). polymorphisms were significantly associated with decreased risk of HIV-1 infection acquisition in the studied Zambian population suggesting that they may play a role in HIV-1 MTCT.

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