The Clinical Manifestation, Survival Outcome and Predictive Prognostic Factors of 137 Patients with Primary Gastrointestinal Lymphoma (PGIL): Strobe Compliant

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2018 Mar 6

PMID 29505542

Citations 8

Authors

Zhan Shi

Hao Ding

Qian Wen Shen

Xin Gang Lu

Jia Yan Chen

Xi Chen

Xi Tang

Affiliations

Soon will be listed here.

Abstract

This retrospective study aimed to investigate clinical characteristics and prognostic factors in patients with primary gastrointestinal lymphoma (PGIL) of Chinese population.From January 2001 to December 2015, 137 patients diagnosed with PGIL were recruited. The clinical features, treatment, and follow-up information were analysed.The median patient age was 62.3 years. With 18.47 months follow-up, the 2-year progress-free survival and overall survival rate was 74.9% and 75.5%, respectively. The overall response rate was 33.6%. Age≥60 years, advanced Lugano staging (≥stage IIE), elevated lactate dehydrogenase (LDH) levels, ≥2 extra-nodal involved sites, National Comprehensive Cancer Network International Prognostic Index (NCCN-IPI)≥4, Ki-67≥50% were associated with worse prognosis in univariate analysis (P < .05). By multivariate analyses, we determined that the involvement of extra-nodal involved sites was the only statistically significant poor prognostic factor in PGIL.Age, staging, LDH levels, NCCN-IPI, Ki-67 especially involvement of multiple extra-nodal sites were associated with poor overall survival of PGIL.

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References

Kim S, Choi C, Mun Y, Oh S, Kang H, Lee S . Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the Consortium for Improving Survival of Lymphoma (CISL). BMC Cancer. 2011; 11:321. PMC: 3160411. DOI: 10.1186/1471-2407-11-321. View

. Japanese gastric cancer treatment guidelines 2010 (ver. 3). Gastric Cancer. 2011; 14(2):113-23. DOI: 10.1007/s10120-011-0042-4. View

Hampson F, Shaw A . Response assessment in lymphoma. Clin Radiol. 2008; 63(2):125-35. DOI: 10.1016/j.crad.2007.10.005. View

Chihara D, Oki Y, Ine S, Kato H, Onoda H, Taji H . Primary gastric diffuse large B-cell Lymphoma (DLBCL): analyses of prognostic factors and value of pretreatment FDG-PET scan. Eur J Haematol. 2010; 84(6):493-8. DOI: 10.1111/j.1600-0609.2010.01426.x. View

Bautista-Quach M, Ake C, Chen M, Wang J . Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features. J Gastrointest Oncol. 2012; 3(3):209-25. PMC: 3418529. DOI: 10.3978/j.issn.2078-6891.2012.024. View

Cheson B, Pfistner B, Juweid M, Gascoyne R, Specht L, Horning S . Revised response criteria for malignant lymphoma. J Clin Oncol. 2007; 25(5):579-86. DOI: 10.1200/JCO.2006.09.2403. View

Huang J, Jiang W, Xu R, Huang H, Lv Y, Xia Z . Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors. BMC Cancer. 2010; 10:358. PMC: 2914701. DOI: 10.1186/1471-2407-10-358. View

Herrmann R, Panahon A, Barcos M, Walsh D, Stutzman L . Gastrointestinal involvement in non-Hodgkin's lymphoma. Cancer. 1980; 46(1):215-22. DOI: 10.1002/1097-0142(19800701)46:1<215::aid-cncr2820460136>3.0.co;2-6. View

Song L, Cen X, Ou J, Liang Z, Qiu Z, Wang W . [Clinical and prognostic analysis of 101 cases of primary gastrointestinal non-Hodgkin's lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013; 21(2):387-91. DOI: 10.7534/j.issn.1009-2137.2013.02.026. View

10.

Zhou Z, Sehn L, Rademaker A, Gordon L, LaCasce A, Crosby-Thompson A . An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era. Blood. 2013; 123(6):837-42. PMC: 5527396. DOI: 10.1182/blood-2013-09-524108. View

11.

Mehmet K, Sener C, Uyeturk U, Seker M, Tastekin D, Tonyali O . Treatment modalities in primary gastric lymphoma: the effect of rituximab and surgical treatment. A study by the Anatolian Society of Medical Oncology. Contemp Oncol (Pozn). 2014; 18(4):273-8. PMC: 4171466. DOI: 10.5114/wo.2014.40556. View

12.

Shawky H, Tawfik H . Primary Gastrointestinal Non-Hodgkin's Lymphoma: A Retrospective Study with Emphasis on Prognostic Factors and Treatment Outcome. J Egypt Natl Canc Inst. 2010; 20(4):330-41. View

13.

Yoon S, Coit D, Portlock C, Karpeh M . The diminishing role of surgery in the treatment of gastric lymphoma. Ann Surg. 2004; 240(1):28-37. PMC: 1356371. DOI: 10.1097/01.sla.0000129356.81281.0c. View

14.

Koch P, del Valle F, Berdel W, Willich N, Reers B, Hiddemann W . Primary gastrointestinal non-Hodgkin's lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol. 2001; 19(18):3861-73. DOI: 10.1200/JCO.2001.19.18.3861. View

15.

DAWSON I, Cornes J, MORSON B . Primary malignant lymphoid tumours of the intestinal tract. Report of 37 cases with a study of factors influencing prognosis. Br J Surg. 1961; 49:80-9. DOI: 10.1002/bjs.18004921319. View

16.

Ansell S, Armitage J . Non-Hodgkin lymphoma: diagnosis and treatment. Mayo Clin Proc. 2005; 80(8):1087-97. DOI: 10.4065/80.8.1087. View

17.

Khosla D, Kumar R, Kapoor R, Kumar N, Bera A, Sharma S . A retrospective analysis of clinicopathological characteristics, treatment, and outcome of 27 patients of primary intestinal lymphomas. J Gastrointest Cancer. 2013; 44(4):417-21. DOI: 10.1007/s12029-013-9519-1. View

18.

Doglioni C, Ponzoni M, Ferreri A, Savio A . Gastric lymphoma: the histology report. Dig Liver Dis. 2011; 43 Suppl 4:S310-8. DOI: 10.1016/S1590-8658(11)60587-2. View

19.

Nakamura S, Matsumoto T, Iida M, Yao T, Tsuneyoshi M . Primary gastrointestinal lymphoma in Japan: a clinicopathologic analysis of 455 patients with special reference to its time trends. Cancer. 2003; 97(10):2462-73. DOI: 10.1002/cncr.11415. View

20.

Stanojevic G, Nestorovic M, Brankovic B, Stojanovic M, Jovanovic M, Radojkovic M . Primary colorectal lymphoma: An overview. World J Gastrointest Oncol. 2011; 3(1):14-8. PMC: 3026053. DOI: 10.4251/wjgo.v3.i1.14. View