Vitamin D-binding Protein and Its Polymorphisms As a Predictor for Metabolic Syndrome

Overview

Journal Biomark Med

Specialties Biochemistry
General Medicine

Date 2018 Mar 6

PMID 29504805

Citations 8

Authors

Piyaporn Karuwanarint

Benjaluck Phonrat

Anchalee Tungtrongchitr

Kanjana Suriyaprom

Somlak Chuengsamarn

Florian J Schweigert

Rungsunn Tungtrongchitr

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the relationship of vitamin D-binding protein (GC) and genetic variation of GC (rs4588, rs7041 and rs2282679) with metabolic syndrome (MetS) in the Thai population.

Materials & Methods: GC-globulin concentrations were measured by quantitative western blot analysis in 401 adults. All participants were genotyped using TaqMan allelic discrimination assays.

Results: GC-globulin levels were significatly lower in MetS subjects than in control subjects, in which significant negative correlations of GC-globulin levels with systolic blood pressure, glucose and age were found. Male participants who carried the GT genotype for rs4588 showed an increased risk of MetS compared with the GG wild-type (odds ratio: 3.25; p = 0.004).

Conclusion: GC-globulin concentrations and variation in GC rs4588 were supported as a risk factor for MetS in Thais.

Citing Articles

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Unravelling the Contribution of the rs7041 and rs4588 Polymorphisms of the Gene and Serum VDBP Levels for Developing Metabolic Syndrome in the Mexican Population.

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The Association Between Gene Polymorphisms and Metabolic Syndrome in Chinese Rural Population: A Case-Control Study.

Zhao T, Zhang D, Liu Y, Feng M, Xu Z, Huang H Diabetes Metab Syndr Obes. 2022; 15:165-174.

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