A Longitudinal Study of a Chinese Man Presenting with Non-Fluent/Agrammatic Variant of Primary Progressive Aphasia

Overview

Journal Front Neurol

Specialty Neurology

Date 2018 Mar 6

PMID 29503630

Citations 4

Authors

Xiaoyan Liu

Fangping He

Zhongqin Chen

Ping Liu

Guoping Peng

Affiliations

Soon will be listed here.

Abstract

Primary progressive aphasia (PPA) is a neurodegenerative disease characterized by declining language ability. However, the difficulty in defining the central clinical features in its earliest stage and establishing the dynamics of its progression has led to controversy. We report a 71-year-old man with Han language suffering from non-fluent/agrammatic variant of PPA but presenting as typical Alzheimer's disease (AD) and confused with logopenic variant of PPA in its early stage, longitudinally describing his clinical characteristics, neuroanatomical basis, and genetic associations, and exploring the underlying pathology. This case highlights a longitudinal data for reliably discriminating among AD and PPA variants and helps to deepen our understanding of Han language non-fluent/agrammatic variant of PPA.

Citing Articles

Dyslexia and dysgraphia of primary progressive aphasia in Chinese: A systematic review.

Liu J, Ota S, Kawakami N, Kanno S, Suzuki K Front Neurol. 2022; 13:1025660.

PMID: 36561305 PMC: 9764844. DOI: 10.3389/fneur.2022.1025660.

Case Report: A neurolinguistic and neuroimaging study on a Chinese follow-up case with logopenic-variant of primary progressive aphasia.

Huang B, Wang X, Jiang B, Kong L, Hou H, Zhou J Front Neurol. 2022; 13:963970.

PMID: 36203977 PMC: 9530806. DOI: 10.3389/fneur.2022.963970.

Dysgraphia Phenotypes in Native Chinese Speakers With Primary Progressive Aphasia.

Tee B, Lorinda Kwan-Chen L, Chen T, Yan C, Tsoh J, Chan A Neurology. 2022; 98(22):e2245-e2257.

PMID: 35410909 PMC: 9162166. DOI: 10.1212/WNL.0000000000200350.

Aphasia in Alzheimer's Disease and Other Dementias (ADOD): Evidence From Chinese.

Weekes B Am J Alzheimers Dis Other Demen. 2020; 35:1533317520949708.

PMID: 33040568 PMC: 10624002. DOI: 10.1177/1533317520949708.

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