Role of the Nervous System in Tumor Angiogenesis

Overview

Journal Cancer Microenviron

Publisher Springer

Specialty Oncology

Date 2018 Mar 5

PMID 29502307

Citations 23

Authors

Nyanbol Kuol

Lily Stojanovska

Vasso Apostolopoulos

Kulmira Nurgali

Affiliations

Soon will be listed here.

Abstract

The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Tumor angiogenesis, growth of new blood vessels, is one of the major prerequisites for tumor growth as tumor cells rely on adequate oxygen and nutrient supply as well as the removal of waste products. Growth factors including VEGF orchestrate the development of angiogenesis. In addition, nervous system via the release of neurotransmitters contributes to tumor angiogenesis. The nervous system governs functional activities of many organs, and, as tumors are not independent organs within an organism, this system is integrally involved in tumor growth and progression via regulating tumor angiogenesis. Various neurotransmitters have been reported to play an important role in tumor angiogenesis.

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