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AMPKα Inactivation Destabilizes Atherosclerotic Plaque in Streptozotocin-induced Diabetic Mice Through AP-2α/miRNA-124 Axis

Overview

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2018 Mar 5

PMID 29502204

Citations 19

Authors

Authors

Wen-Jing Liang

Sheng-Nan Zhou

Mei-Rong Shan

Xue-Qin Wang

Miao Zhang

Yuan Chen

Yun Zhang

Shuang-Xi Wang

Tao Guo

Affiliations

Affiliations

Soon will be listed here.

Abstract

Key Messages: Hyperglycemia reduced collagen synthesis, leading to the formation of unstable atherosclerotic plaque induced by collar placement around carotid in apolipoprotein E knockout mice. Hyperglycemia destabilizes atherosclerotic plaque in vivo through an AMPKα/AP-2α/miRNA-124/P4Hα1-dependent collagen synthesis. Metformin functions as a stabilizer of atherosclerotic plaque to reduce acute coronary accent.

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References

1.

Ido Y, Carling D, Ruderman N . Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 2002; 51(1):159-67. DOI: 10.2337/diabetes.51.1.159. View

2.

Shafrir E . Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia. Diabetes Metab. 1996; 22(2):122-31. View

3.

Wang S, Xu J, Song P, Viollet B, Zou M . In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I. Diabetes. 2009; 58(8):1893-901. PMC: 2712774. DOI: 10.2337/db09-0267. View

4.

Lopez M, Nogueiras R, Tena-Sempere M, Dieguez C . Hypothalamic AMPK: a canonical regulator of whole-body energy balance. Nat Rev Endocrinol. 2016; 12(7):421-32. DOI: 10.1038/nrendo.2016.67. View

5.

Nagareddy P, Murphy A, Stirzaker R, Hu Y, Yu S, Miller R . Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab. 2013; 17(5):695-708. PMC: 3992275. DOI: 10.1016/j.cmet.2013.04.001. View

6.

Nakashima Y, Plump A, Raines E, Breslow J, Ross R . ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994; 14(1):133-40. DOI: 10.1161/01.atv.14.1.133. View

7.

Donahoe S, Stewart G, McCabe C, Mohanavelu S, Murphy S, Cannon C . Diabetes and mortality following acute coronary syndromes. JAMA. 2007; 298(7):765-75. DOI: 10.1001/jama.298.7.765. View

8.

Parathath S, Grauer L, Huang L, Sanson M, Distel E, Goldberg I . Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice. Diabetes. 2011; 60(6):1759-69. PMC: 3114401. DOI: 10.2337/db10-0778. View

9.

Low Wang C, Hess C, Hiatt W, Goldfine A . Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus - Mechanisms, Management, and Clinical Considerations. Circulation. 2016; 133(24):2459-502. PMC: 4910510. DOI: 10.1161/CIRCULATIONAHA.116.022194. View

10.

Zang M, Xu S, Maitland-Toolan K, Zuccollo A, Hou X, Jiang B . Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes. 2006; 55(8):2180-91. DOI: 10.2337/db05-1188. View

11.

Rocnik E, Chan B, Pickering J . Evidence for a role of collagen synthesis in arterial smooth muscle cell migration. J Clin Invest. 1998; 101(9):1889-98. PMC: 508775. DOI: 10.1172/JCI1025. View

12.

Yang J, Li P, Wang F, Liang W, Ma H, Chen Y . Activation of activator protein 2 alpha by aspirin alleviates atherosclerotic plaque growth and instability in vivo. Oncotarget. 2016; 7(33):52729-52739. PMC: 5288144. DOI: 10.18632/oncotarget.10400. View

13.

Utsugi T, Yoon J, Park B, Imamura M, Averill N, Kawazu S . Major histocompatibility complex class I-restricted infiltration and destruction of pancreatic islets by NOD mouse-derived beta-cell cytotoxic CD8+ T-cell clones in vivo. Diabetes. 1996; 45(8):1121-31. DOI: 10.2337/diab.45.8.1121. View

14.

Magnusson S, Heinemeier K, Kjaer M . Collagen Homeostasis and Metabolism. Adv Exp Med Biol. 2016; 920:11-25. DOI: 10.1007/978-3-319-33943-6_2. View

15.

Rhoades M, Reinhart B, Lim L, Burge C, Bartel B, Bartel D . Prediction of plant microRNA targets. Cell. 2002; 110(4):513-20. DOI: 10.1016/s0092-8674(02)00863-2. View

16.

Myllyharju J . Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis. Matrix Biol. 2003; 22(1):15-24. DOI: 10.1016/s0945-053x(03)00006-4. View

17.

von der Thusen J, Van Berkel T, Biessen E . Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Circulation. 2001; 103(8):1164-70. DOI: 10.1161/01.cir.103.8.1164. View

18.

Kivirikko K, Helaakoski T, Tasanen K, Vuori K, Myllyla R, Parkkonen T . Molecular biology of prolyl 4-hydroxylase. Ann N Y Acad Sci. 1990; 580:132-42. DOI: 10.1111/j.1749-6632.1990.tb17925.x. View

19.

Li Y, Xu S, Mihaylova M, Zheng B, Hou X, Jiang B . AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011; 13(4):376-388. PMC: 3086578. DOI: 10.1016/j.cmet.2011.03.009. View

20.

Iwamoto N, Abe-Dohmae S, Lu R, Yokoyama S . Involvement of protein kinase D in phosphorylation and increase of DNA binding of activator protein 2 alpha to downregulate ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 2008; 28(12):2282-7. DOI: 10.1161/ATVBAHA.108.174714. View