Association Between Vitamin D Metabolism Gene Polymorphisms and Risk of Tunisian Adults' Asthma

Overview

Journal Lung

Specialty Pulmonary Medicine

Date 2018 Mar 5

PMID 29502202

Citations 3

Authors

Oussama Lahmar

Mariem Salhi

Wajih Kaabachi

Anissa Berraies

Jamel Ammar

Munawar Hussain Soomro

Martin Larsen

Isabella Annesi-Maesano

Kamel Hamzaoui

Agnes Hamzaoui

Affiliations

Soon will be listed here.

Abstract

Introduction: Several studies have shown a strong correlation between the serum vitamin D level and asthma severity and deficits in lung function.

Objective: Study the relationship between vitamin D and the severity of asthma by targeting five SNPs of vitamin D metabolism gene pathway in a Tunisian adult asthmatics population.

Methods: Our case-control study includes 154 adult asthmatic patients and 154 healthy Tunisian subjects. We genotyped many variants in three human genes encoding key components of the vitamin D metabolism, CYP2R1, CYP27B1, GC. The GC gene rs4588 and rs7041 polymorphisms were analysed using the PCR-RFLP method, while rs10741657 and rs12794714 for CYP2R1 gene and rs10877012 of CYP27B1 gene were investigated using TaqMan PCR genotyping techniques.

Results: We found that the presence of at least one copy of the rs12794714 A, allele was associated with lower risk of developing asthma (OR 0.61). Further, the rs12794714 is a protector factor against asthma severity (OR 0.5). However, the presence of rs10877012 TG genotype is a risk factor related to asthma severity (OR 1.89). When we classified the population according to sex, our results showed that rs10877012 TT genotype was a risk factor for women subjects (OR 6.7). Moreover, the expression of TT genotype was associated with a higher risk of asthma in non-smoker patients (OR 7.13). We found a significant lower VD serum levels in asthmatics than controls but no impact of the polymorphisms on VD levels.

Conclusions: We found that rs12794714 and rs10877012 SNPs were associated with asthma risk.

Citing Articles

Vitamin D metabolism-related single nucleotide polymorphisms in Chronic Obstructive Pulmonary Disease risk.

Rojo-Tolosa S, Pineda-Lancheros L, Fernandez-Alonso A, Marquez-Pete N, Cura Y, Membrive-Jimenez C Front Endocrinol (Lausanne). 2024; 15:1445712.

PMID: 39583968 PMC: 11581940. DOI: 10.3389/fendo.2024.1445712.

Analysis of single nucleotide polymorphisms associated with the vitamin D pathway in the placentas of women with gestational diabetes mellitus: a laboratory study.

Kim M, Kim H, Cha H, Seong W J Yeungnam Med Sci. 2023; 40(Suppl):S9-S16.

PMID: 37157780 PMC: 10718604. DOI: 10.12701/jyms.2023.00150.

Association between Single Nucleotide Polymorphisms Related to Vitamin D Metabolism and the Risk of Developing Asthma.

Rojo-Tolosa S, Pineda-Lancheros L, Galvez-Navas J, Sanchez-Martinez J, Gonzalez-Gutierrez M, Fernandez-Alonso A Nutrients. 2023; 15(4).

PMID: 36839181 PMC: 9964183. DOI: 10.3390/nu15040823.

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