Monoclonal Anti-Ia Antibodies Suppress the Flare Up Reaction of Antigen Induced Arthritis in Mice

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1986 Nov 1

PMID 2949898

Citations 9

Authors

M F van den Broek

W B van den Berg

L B van de Putte

Affiliations

Soon will be listed here.

Abstract

Intravenous injection of methylated bovine serum albumin (mBSA) in mice with a unilateral antigen-induced arthritis induced with mBSA causes a flare up of the inflammation in the arthritic but not in the contralateral joint. To study whether this phenomenon is dependent on class II antigens, we treated C57Bl/10 (H-2b) and C3H (H-2k) mice with monoclonal anti-Iab (HB26) and anti-Iak (2-2-1) antibodies on days -3, -2, -1 and 0 before induction of the flare up. Another group was treated only once on day 0 before antigen challenge. Four injections with HB26 completely suppressed the flare up reaction in C57Bl/10 mice; the same results were seen with 2-2-1 in C3H mice. One injection only partly suppressed the flare up reaction in both strains, whereas four injections with the haplotype-nonspecific antibodies did not affect the flare up. Injections with HB26 appeared to be able to completely suppress a delayed type hypersensitivity reaction but not a reversed passive Arthus reaction in C57B1/10 mice, indicating that anti-Ia antibodies have an effect on lymphocyte-dependent but not on antigen-antibody-dependent inflammatory phenomena. These results demonstrate that the flare up of antigen induced arthritis is dependent on the presence of Ia antigens, suggesting that the interaction between antigen-presenting cells and T lymphocytes plays an important role in this process.

Citing Articles

Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.

Koenders M, Lubberts E, Oppers-Walgreen B, van den Bersselaar L, Helsen M, Di Padova F Am J Pathol. 2005; 167(1):141-9.

PMID: 15972960 PMC: 1603454. DOI: 10.1016/S0002-9440(10)62961-6.

Role of interleukin 1 in antigen-induced exacerbations of murine arthritis.

van de Loo A, Arntz O, Bakker A, van Lent P, Jacobs M, van den Berg W Am J Pathol. 1995; 146(1):239-49.

PMID: 7856731 PMC: 1870767.

Role of IL-2 and IL-4 in exacerbations of murine antigen-induced arthritis.

Jacobs M, van den Hoek A, van Lent P, van De Loo F, van de Putte L, van den Berg W Immunology. 1994; 83(3):390-6.

PMID: 7835964 PMC: 1415042.

The role of MHC class II antigens in the flare up reaction of antigen-induced arthritis in mice.

van den Broek M, van den Berg W, van de Putte L Agents Actions. 1986; 19(5-6):328-30.

PMID: 3469892 DOI: 10.1007/BF01971241.

van Beuningen H, van den Berg W, Schalkwijk J, Arntz O, van de Putte L Agents Actions. 1988; 23(1-2):74-6.

PMID: 3354392 DOI: 10.1007/BF01967193.

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