Intravenous Immunoglobulin Fails to Improve ARDS in Patients Undergoing ECMO Therapy

Overview

Journal J Intensive Care

Publisher Biomed Central

Specialty Critical Care

Date 2018 Mar 3

PMID 29497534

Citations 2

Authors

Stefanie Prohaska

Andrea Schirner

Albina Bashota

Andreas Korner

Gunnar Blumenstock

Helene A Haeberle

Affiliations

Soon will be listed here.

Abstract

Background: Acute respiratory distress syndrome (ARDS) is associated with high mortality rates. ARDS patients suffer from severe hypoxemia, and extracorporeal membrane oxygenation (ECMO) therapy may be necessary to ensure oxygenation. ARDS has various etiologies, including trauma, ischemia-reperfusion injury or infections of various origins, and the associated immunological responses may vary. To support the immunological response in this patient collective, we used intravenous IgM immunoglobulin therapy to enhance the likelihood of pulmonary recovery.

Methods: ARDS patients admitted to the intensive care unit (ICU) who were placed on ECMO and treated with (IVIG group; = 29) or without (control group; = 28) intravenous IgM-enriched immunoglobulins for 3 days in the initial stages of ARDS were analyzed retrospectively.

Results: The baseline characteristics did not differ between the groups, although the IVIG group showed a significantly reduced oxygenation index compared to the control group. We found no differences in the length of ICU stay or ventilation parameters. We did not find a significant difference between the groups for the extent of inflammation or for overall survival.

Conclusion: We conclude that administration of IgM-enriched immunoglobulins as an additional therapy did not have a beneficial effect in patients with severe ARDS requiring ECMO support.

Trial Registration: Clinical Trials: NCT02961166; retrospectively registered.

Citing Articles

Potential therapeutic approach of intravenous immunoglobulin against COVID-19.

Kolahchi Z, Sohrabi H, Ekrami Nasab S, Mamaghani H, Keyfari Alamdari M, Rezaei N Allergy Asthma Clin Immunol. 2021; 17(1):105.

PMID: 34627384 PMC: 8501925. DOI: 10.1186/s13223-021-00609-3.

The use of intravenous immunoglobulin gamma for the treatment of severe coronavirus disease 2019: a randomized placebo-controlled double-blind clinical trial.

Gharebaghi N, Nejadrahim R, Mousavi S, Sadat-Ebrahimi S, Hajizadeh R BMC Infect Dis. 2020; 20(1):786.

PMID: 33087047 PMC: 7576972. DOI: 10.1186/s12879-020-05507-4.

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