Microplastic Pollution Increases Gene Exchange in Aquatic Ecosystems
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Pollution by microplastics in aquatic ecosystems is accumulating at an unprecedented scale, emerging as a new surface for biofilm formation and gene exchange. In this study, we determined the permissiveness of aquatic bacteria towards a model antibiotic resistance plasmid, comparing communities that form biofilms on microplastics vs. those that are free-living. We used an exogenous and red-fluorescent E. coli donor strain to introduce the green-fluorescent broad-host-range plasmid pKJK5 which encodes for trimethoprim resistance. We demonstrate an increased frequency of plasmid transfer in bacteria associated with microplastics compared to bacteria that are free-living or in natural aggregates. Moreover, comparison of communities grown on polycarbonate filters showed that increased gene exchange occurs in a broad range of phylogenetically-diverse bacteria. Our results indicate horizontal gene transfer in this habitat could distinctly affect the ecology of aquatic microbial communities on a global scale. The spread of antibiotic resistance through microplastics could also have profound consequences for the evolution of aquatic bacteria and poses a neglected hazard for human health.
Wu X, He F, Xu X, Wu L, Rong J, Lin S Environ Health (Wash). 2025; 3(2):118-132.
PMID: 40012871 PMC: 11851218. DOI: 10.1021/envhealth.4c00148.
Characteristics of phage-plasmids and their impact on microbial communities.
Sayid R, van den Hurk A, Rothschild-Rodriguez D, Herrema H, de Jonge P, Nobrega F Essays Biochem. 2024; 68(5):583-592.
PMID: 39611587 PMC: 11652158. DOI: 10.1042/EBC20240014.
Jia J, Liu Q, Zhao E, Li X, Xiong X, Wu C Eco Environ Health. 2024; 3(4):516-528.
PMID: 39605964 PMC: 11599983. DOI: 10.1016/j.eehl.2024.05.003.
The adsorption of drugs on nanoplastics has severe biological impact.
Dick L, Batista P, Zaby P, Manhart G, Kopatz V, Kogler L Sci Rep. 2024; 14(1):25853.
PMID: 39468142 PMC: 11519658. DOI: 10.1038/s41598-024-75785-4.
Aged Microplastics and Antibiotic Resistance Genes: A Review of Aging Effects on Their Interactions.
Tang K, Li R Antibiotics (Basel). 2024; 13(10).
PMID: 39452208 PMC: 11504238. DOI: 10.3390/antibiotics13100941.