Mind-altering with the Gut: Modulation of the Gut-brain Axis with Probiotics

Overview

Journal J Microbiol

Specialty Microbiology

Date 2018 Mar 2

PMID 29492874

Citations 82

Authors

Namhee Kim

Misun Yun

Young Joon Oh

Hak-Jong Choi

Affiliations

Soon will be listed here.

Abstract

It is increasingly evident that bidirectional interactions exist among the gastrointestinal tract, the enteric nervous system, and the central nervous system. Recent preclinical and clinical trials have shown that gut microbiota plays an important role in these gut-brain interactions. Furthermore, alterations in gut microbiota composition may be associated with pathogenesis of various neurological disorders, including stress, autism, depression, Parkinson's disease, and Alzheimer's disease. Therefore, the concepts of the microbiota-gut-brain axis is emerging. Here, we review the role of gut microbiota in bidirectional interactions between the gut and the brain, including neural, immune-mediated, and metabolic mechanisms. We highlight recent advances in the understanding of probiotic modulation of neurological and neuropsychiatric disorders via the gut-brain axis.

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