Mast Cells and Angiogenesis in Pancreatic Ductal Adenocarcinoma
Overview
Authors
Affiliations
Mast cells are recognized as critical components of the tumor stromal microenvironment in several solid and hematological malignancies, promoting angiogenesis and tumor growth. A correlation between mast cells infiltration, angiogenesis and tumor progression has been reported for pancreatic ductal adenocarcinoma as well. Mast cells contribute to the aggressiveness of the pancreatic ductal carcinoma enhancing the expression of several pro-angiogenic factors such as vascular endothelial growth factor, fibroblast growth factor-2, platelet-derived growth factor and angiopoietin-1 as well as stimulating the pancreatic cancer cells proliferation by IL-13 and tryptase. The disruption of this pro-angiogenic and proliferative stimulation by inhibiting the mast cells migration and degranulation is under investigation as a potential therapeutic approach in pancreatic ductal adenocarcinoma patients. This review will summarize the literature concerning the mast cells infiltration in the pancreatic ductal adenocarcinoma analyzing its role in angiogenesis and tumor progression.
Immunomodulatory Significance of Mast Cell Exosomes (MC-EXOs) in Immune Response Coordination.
Elieh-Ali-Komi D, Shafaghat F, Alipoor S, Kazemi T, Atiakshin D, Pyatilova P Clin Rev Allergy Immunol. 2025; 68(1):20.
PMID: 39976807 PMC: 11842441. DOI: 10.1007/s12016-025-09033-6.
gene expression as a prognostic marker for clinical outcomes in lung adenocarcinoma.
Qiu L, Li T, Qing B, Zhao C, Zhang X, Watanabe S Transl Lung Cancer Res. 2025; 14(1):224-238.
PMID: 39958209 PMC: 11826265. DOI: 10.21037/tlcr-24-623.
Mast cells: key players in digestive system tumors and their interactions with immune cells.
Shu F, Yu J, Liu Y, Wang F, Gou G, Wen M Cell Death Discov. 2025; 11(1):8.
PMID: 39814702 PMC: 11735678. DOI: 10.1038/s41420-024-02258-y.
Renal Mast Cell-Specific Proteases in the Pathogenesis of Tubulointerstitial Fibrosis.
Atiakshin D, Morozov S, Dlin V, Kostin A, Volodkin A, Ignatyuk M J Histochem Cytochem. 2024; 72(8-9):495-515.
PMID: 39263893 PMC: 11529666. DOI: 10.1369/00221554241274878.
Ribatti D Front Med (Lausanne). 2024; 11:1373230.
PMID: 38482531 PMC: 10933100. DOI: 10.3389/fmed.2024.1373230.