Mortality in Robin Sequence: Identification of Risk Factors

Overview

Journal Eur J Pediatr

Specialty Pediatrics

Date 2018 Mar 2

PMID 29492661

Citations 13

Authors

Robrecht J H Logjes

Maartje Haasnoot

Petra M A Lemmers

Mike F A Nicolaije

Marie-Jose H van den Boogaard

Aebele B Mink van der Molen

Corstiaan C Breugem

Affiliations

Soon will be listed here.

Abstract

Conclusion: RS represents a heterogeneous patient population and is associated with a high level of underlying syndromes. The present study reports a mortality rate of 10% significantly associated with syndromic RS and the presence of neurological anomalies. A multidisciplinary approach in all infants born with RS, including genetic testing and examination of neurological anomalies in a standardized way, is crucial to identify infants with underlying syndromes potentially associated with increased mortality. What is Known: • Reported mortality rates in Robin sequence vary from 2% to 26%. • Clinicians mainly focus on the morbidity of Robin sequence that includes respiratory complications due to upper airway obstruction in the period after birth. • Robin sequence represents a heterogeneous patient population and is associated with a high level of underlying syndromes. What is New: • The present study reports a mortality rate of 10% significantly associated with syndromic Robin sequence and the presence of neurological anomalies. • A multidisciplinary approach in all infants born with Robin sequence, including genetic evaluation and standardized workup for neurological anomalies, is crucial to identify infants with underlying syndromes potentially associated with increased mortality.

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